Peripheral oxygenation targets in critically ill children: Pilot Oxy-PICU definitive trial

Feasibility of a definitive trial of peripheral oxygenation targets in critically ill children: pilot Oxy-PICU trial EJRC Article Review Although peripheral oxygen saturation (SpO2) monitoring is universal, the optimum target for ventilated critically ill children is uncertain. Lower SpO2targets at 85-89% is favoured in preterm infants [1]. In adults, reported mean number needed to harm […]

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How accurate are predictive outcomes for ventilator-associated events?

How accurate are predictive outcomes for ventilator-associated events? Results from the EUVAE study In 2013, the Centre for Disease Control and Prevention (CDC) proposed (and in 2015 updated) a new diagnostic algorithm for ventilator-associated events (VAEs) based on more objective criteria and easily measurable clinical features [1,2]. The algorithm divides the causes of respiratory worsening in […]

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Augmented renal clearance: Impact on continuously infused TZP concentrations?

Does augmented renal clearance have a negative impact on continuously infused TZP concentrations? EJRC Article Review Inappropriate antibiotic dosing has been linked to adverse infection outcomes1,2. Augmented renal clearance (ARC, >130mL/min) has been identified as a risk factor for low beta-lactam antibiotic concentrations in ICU patients 5,6. Because beta-lactam antibiotics have time-dependent killing properties, prolonging […]

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e-LIVES: October Highlights

e-LIVES: October Highlights Special interest sessions @LIVES 2018 This month we feature 6 top sessions which will be on offer at LIVES 2018 in Paris: Changing the paradigm: Personalised antibiotic dosing for the critically ill 22.10.2018 08:00-08:20 Presidents’ Ground Breaking Research Release 22.10.2018 16:00-18:11 ARDS phenotyping: A new era for clinical trials? 23.10.2018 08:00-08:20 Clinical […]

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Ventilator-associated complications in patients with ESBLE infections

Ventilator-associated complications in patients with ESBLE infections EJRC Article Review   Extended-spectrum b-lactamase producing Enterobacteriaceae (ESBLE) colonise a growing proportion of critically ill patients in the intensive care unit (ICU)[1]. ESBLE colonisation is an established risk factor for subsequent infections [2]. Although guidelines suggest to consider the colonisation status of patients to adjust empirical treatment […]

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Intensive Care Medicine: Access the latest ONLINE FIRST papers

ICM ONLINE FIRST THIS WEEK (FREE ACCESS) Review ~ Mohamed Abbas et al. Conflicts of interest in infection prevention and control research: no smoke without fire. A narrative review. From the Inside ~ Han Yan and Keegan Guidolin. Her ICU bed. Original ~ Lara Hessels et al. Urinary creatinine excretion is related to short-term and […]

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e-LIVES: September webcast highlights

e-LIVES: September Highlights Top Acute Kidney Injury (AKI) Sessions   This month we feature 3 top sessions from LIVES 2017 in Vienna selected by Section Chair Eric Hoste: How will I prevent and treat AKI next year? Oliguria: What is the kidney telling us? An early start for RRT? This EXCLUSIVE CONTENT is available for all […]

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e-LIVES: July/August webcast highlights

e-LIVES: July/August Highlights Top Metabolism, Endocrinology & Nutrition (MEN) Sessions   This month we feature 3 top sessions from LIVES 2017 in Vienna selected by Section Chair Carole Ichai: Personalised nutritional support Chloride: An underestimated foe Hyperlactataemia in sepsis This EXCLUSIVE CONTENT is available for all on our e-LIVES platform for a limited time… Watch these webcasts now!   […]

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Is Trimodulin a safe and beneficial adjuvant therapy for adult patients with sCAP?

Is Trimodulin a safe and beneficial adjuvant therapy for adult patients with sCAP? EJRC Article Review Severe community-acquired pneumonia (sCAP) remains associated with high mortality despite widespread use of supportive care and targeted antibiotic therapy. Evidence suggests that IgM-enriched Immunoglobulin preparations are associated with a decrease in mortality in severe sepsis and septic shock. In […]

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