ESICM’S 2019 Research Awards

The ESICM Research and Industry Awards offer “something for everyone”, from junior to more experienced researchers, and from basic to clinical research.

Jan De Waele, Chair of the ESICM Research Committee, outlines the new process and different categories of awards.

The first step of 2019 ESICM Award application is completed. Pre-selected candidate will be contacted shortly to fill out the full application.

SIS News

Section and working groups

The Systemic Inflammation and Sepsis section is led by Ricard Ferrer-Roca and Massimo Girardis.

> Learn more about this section

Latest Developments

Experts have reiterated the need to go back to the drawing board (so to speak) and re-focus on basic science with pre-clinical trials. However, one of the criticisms related to this type of sepsis research is a lack of homogeneity in animal study design.

Pre-clinical sepsis guidelines are important for ICM, they can raise awareness of sepsis and enhance the translational value of animal studies in pre-clinical trials.

Read the international expert consensus initiative for improvement of animal modelling in sepsis – Minimum quality threshold in pre-clinical sepsis studies (MATiPSS), here.

A number of important, key messages were agreed at last month’s meeting of the European Sepsis Alliance. The meeting took place in Brussels on 18 March and brought together healthcare professionals, policymakers, researchers, and industry representatives, as well as patient and family representatives. The European Sepsis Alliance calls for a joint action.

It was highlighted at the meeting that interdisciplinary action is needed to tackle sepsis because at its core it is a challenge at many levels. Sepsis is considered the most preventable cause of death and disability in Europe.

Read our report here.

Key messages:
*The inclusion of patients and families in future discussions
*The creation of a network and guidelines created by an interdisciplinary committee, e.g. intensivists, nurses, microbiologists, etc
*Creation and implementation of national strategies, taking into account countries’ specificities
*Creation of an action plan at EU-level
*Sharing of good practices among disciplines and countries
*Creation of an awareness campaign for laypersons and policymakers
*Improved training of healthcare professionals

Research – Research Projects

Sepsis Assessment and Identification in Low Resource Settings (SAILORS). SAILORS Study Group, ESICM, SCCM collaboration.

> Abstract

Info
Incidence of severe sepsis and septic shock

> ICM Pulse

A one-day observational study on sepsis and septic shock carried out by ESICM and SCCM under the framework of the SSC.

> Read more

Publication
The Surviving Sepsis Campaign bundles and outcome: results from the International Multicentre Prevalence Study on Sepsis (the IMPreSS study).

> Read more

> Learn more about the  Surviving  Sepsis Campaign

Abdominal Sepsis Study: Epidemiology of Etiology and Outcome is a multinational, prospective, observational study on intra-abdominal infections (IAIs) in critically ill patients with a special emphasis on epidemiology and outcomes.

Investigate microbiology and/or drug resistance patterns. Describe physician’s antimicrobial prescription patterns. Investigate outcomes (clinical response, need for surgical revision, length of hospitalisation, and mortality).

Last update

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A genetic epidemiologic study of genetic predisposition to sepsis-related mortality and morbidity in European intensive care units.

For further information www.genosept.eu

Publications
Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort
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Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study
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Association between trends in clinical variables and outcome in intensive care patients with faecal peritonitis: analysis of the GenOSept cohort
Read more

The trial aimed at identifying factors that determine the incidence, severity and the outcome from life-threatening infections (severe sepsis/septic shock) in patients admitted to High Dependency Units (HDUs) or Intensive Care Units (ICUs) with community acquired pneumonia (CAP) or with faecal peritonitis (FP).

Further information: www.ukccg-gains.org

Publication
Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study

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Research – Surveys

The purpose of the GSA Sepsis Quality Measures Global Survey is to characterize the current practices related to sepsis surveillance, treatment, quality improvement, and reporting worldwide.

The survey is organized by the Global Sepsis Alliance.

The survey takes about 7 to 9 minutes, is completely anonymous, and essential to reveal how sepsis is measured and treated around the world.

>Complete the survey

>Learn more

Survey of Current Sepsis Recognition & Management aimed to assess how well the 2012 Surviving Sepsis guidelines are being put into practice.

Letter published in ICM ONLINE FIRST

> Learn more

Relevant research

Marcin F. Osuchowski et al. Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis.
> Read article

Coopersmith, C.M. et al. Surviving Sepsis Campaign: Research priorities for sepsis and septic shock.
> Read article

Urayeneza, O. et al. Increasing evidence-based interventions in patients with acute infections in a resource-limited setting: a before-and-after feasibility trial in Gitwe, Rwanda. 
> Read article

Anders Perner et al. The intensive care medicine research agenda on septic shock.
> Read article

Frank Bloos et al. Effect of a multifaceted educational intervention for anti-infectious measures on sepsis mortality: a cluster randomised trial.
> Read article

Article Reviews

Polymyxin B‑immobilised haemoperfusion and mortality in critically ill adult patients with sepsis/septic shock
> Read the article review

Vitamin C & Thiamine: A cocktail that saves lives in sepsis?
> Read the article review

Acute Kidney Injury in Sepsis
> Read this article review

Fluid administration in severe sepsis and septic shock
> Read this article review

Hydrocortisone & Shock in Patients with Severe Sepsis: HYPRESS
> Read this article review

Surviving Sepsis Campaign

The Surviving Sepsis Campaign (SSC) is a partnership of the European Society of Intensive Care Medicine and the Society of Critical Care Medicine.

Last update:

Levy, M.M., Evans, L.E. & Rhodes, A. The Surviving Sepsis Campaign Bundle: 2018 update.

Relevant information:

Surviving Sepsis Campaign webpage

WORLD HEALTH ASSEMBLY RESOLUTION ON SEPSIS

IMPROVING THE PREVENTION, DIAGNOSIS AND MANAGEMENT OF SEPSIS
On May 26th the World Health Organisation held its 70th assembly in Geneva, Switzerland. During this gathering, 194 United Nations member states voted to affirm a resolution implementing steps to reduce the human and economic burden of sepsis. Outgoing Director-General Dr. Margaret Chan through this resolution, drew attention to these important actions:

  1. Publish a report on sepsis and its global consequences by the end of 2018;
  2. Draw attention to the public impact of sepsis;
  3. Collaborate with other organisations & relevant stakeholders in enhancing access to quality, safe, efficacious and affordable types of treatments of sepsis, and infection prevention and control; and
  4. Report to the 2020 WHA on the implementation of this resolution.

A WHO news release of the resolution is provided here along with the full resolution attached. The European Society of Intensive Care Medicine and the Society of Critical Care Medicine through the Surviving Sepsis Campaign, will be assessing steps  the Campaign will take to contribute and support these vitally important efforts. Please share this resolution information amongst your colleagues at your hospital in acknowledgement that sepsis has now been officially recognised as a global challenge in which we all play an important role worldwide. Thank you all for your dedication to early identification and treatment, antibiotic stewardship and continued vigilance on behalf of the patients we serve.

Awards

Recombinant human IL-7 in the treatment of sepsis: preclinical study in patients and animal model of sepsis.
Fabienne Venet

Implication of MAIT cells and other innate-like lymphocytes in the pathophysiology of septic shock
Frédéric Pene

Suggested videos

Pre-clinical Sepsis Study Guidelines

In this recent icTV interview, lead author of the Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS), Marcin Osuchowski explains the importance of these guidelines for intensive care medicine, how they can raise awareness of sepsis and enhance the translational value of animal studies in pre-clinical trials.

Read the international expert consensus initiative for improvement of animal modelling in sepsis – Minimum Quality Threshold In Pre-clinical Sepsis Studies (MQTiPSS)

SEPSIS: The end of EGDT?

In this icTV interview, Jean-Louis Vincent tackles this and the many other lingering questions related to the treatment and study of sepsis.

Negative vs. neutral trials & future research

Never one to shy away from controversial topics, Intensive Care Medicine (ICM) Deputy Editor Anders Perner holds no punches in this interview on many of the key debates related to current and future sepsis research.

Read the related free access paper in ICM: Anders Perner et al. The intensive care medicine research agenda on septic shock. Intensive Care Med (2017) 43:1294–1305 DOI 10.1007/s00134-017-4821-1

Education

Master Class

Fundamentals & Updates in Sepsis is a 2-day course for intensivists in training who seek to improve their knowledge and update their skills on diagnosis and treatment of systemic inflammation & sepsis.

This master class covers basic concepts, guidelines, resolutions and recommendations on sepsis, pathophysiology, diagnosis, initial resuscitation, source control, failing organs, antibiotics & other therapies.

This interactive session will blend theory with practice. Special attention is given to case-based discussions, workshops and problem-oriented approach.