Section and working groups
The Systemic Inflammation and Sepsis section is led by Yasser Sakr and Massimo Girardis.
Research – Trials
Sepsis Assessment and Identification in Low Resource Settings (SAILORS). SAILORS Study Group, ESICM, SCCM collaboration.
Info
Incidence of severe sepsis and septic shock
A one-day observational study on sepsis and septic shock carried out by ESICM and SCCM under the framework of the SSC.
Publication
The Surviving Sepsis Campaign bundles and outcome: results from the International Multicentre Prevalence Study on Sepsis (the IMPreSS study).
Abdominal Sepsis Study: Epidemiology of Etiology and Outcome is a multinational, prospective, observational study on intra-abdominal infections (IAIs) in critically ill patients with a special emphasis on epidemiology and outcomes.
Investigate microbiology and/or drug resistance patterns. Describe physician’s antimicrobial prescription patterns. Investigate outcomes (clinical response, need for surgical revision, length of hospitalisation, and mortality).
A genetic epidemiologic study of genetic predisposition to sepsis-related mortality and morbidity in European intensive care units.
For further information www.genosept.eu
Publications
Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort
Read more
Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study
Read more
Association between trends in clinical variables and outcome in intensive care patients with faecal peritonitis: analysis of the GenOSept cohort
Read more
The trial aimed at identifying factors that determine the incidence, severity and the outcome from life-threatening infections (severe sepsis/septic shock) in patients admitted to High Dependency Units (HDUs) or Intensive Care Units (ICUs) with community acquired pneumonia (CAP) or with faecal peritonitis (FP).
Further information: www.ukccg-gains.org
Publication
Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study
Research – Surveys
Survey of Current Sepsis Recognition & Management aimed to assess how well the 2012 Surviving Sepsis guidelines are being put into practice.
Letter published in ICM ONLINE FIRST
Relevant research
Coopersmith, C.M. et al. Surviving Sepsis Campaign: Research priorities for sepsis and septic shock.
> Read article (Free Access)
Urayeneza, O. et al. Increasing evidence-based interventions in patients with acute infections in a resource-limited setting: a before-and-after feasibility trial in Gitwe, Rwanda.
> Read article (Free Access)
Anders Perner et al. The intensive care medicine research agenda on septic shock.
> Read article (Free Access)
Frank Bloos et al. Effect of a multifaceted educational intervention for anti-infectious measures on sepsis mortality: a cluster randomised trial.
> Read article (Free Access)
Paul E. Marik et al. Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock – A Retrospective Before-After Study.
> Read more
Ben Andrews et al. Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension
> Read more
Flavia R. Machado et al. Trying to Improve Sepsis Care in Low-Resource Settings
> Read more
Tamara Merz et al. Impact of hyperglycemia on cystathionine-γ-lyase expression during resuscitated murine septic shock.
> Read more
SepNet Critical Care Trials Group. Incidence of severe sepsis and septic shock in German intensive care units: the prospective, multicentre INSEP study.
> Read more
Baseline thrombospondin-1 concentrations are not associated with mortality in septic patients: a single-center cohort study on the intensive care unit
> Read more
Soluble Toll-like receptor 2 is a biomarker for sepsis in critically ill patients with multi-organ failure within 12 h of ICU admission
> Read more
Neuroprotective effects of intravenous immunoglobulin are mediated through inhibition of complement activation and apoptosis in a rat model of sepsis
> Read more
Article Reviews
Polymyxin B‑immobilised haemoperfusion and mortality in critically ill adult patients with sepsis/septic shock
> Read the article review
Vitamin C & Thiamine: A cocktail that saves lives in sepsis?
> Read the article review
Acute Kidney Injury in Sepsis
> Read this article review
Fluid administration in severe sepsis and septic shock
> Read this article review
Hydrocortisone & Shock in Patients with Severe Sepsis: HYPRESS
> Read this article review
SSC Guidelines 2016: Framing better care of patients with Sepsis
> Read this article review
Sepsis-3 Criteria for In-Hospital Mortality: What’s the Prognostic Accuracy?
> Read this article review
Putting them to the test in the ICU: SOFA, SIRS & qSOFA
> Read this article review
Surviving Sepsis Campaign
The Surviving Sepsis Campaign (SSC) is a partnership of the European Society of Intensive Care Medicine and the Society of Critical Care Medicine.
Last update:
Levy, M.M., Evans, L.E. & Rhodes, A. The Surviving Sepsis Campaign Bundle: 2018 update.
Relevant information:
Surviving Sepsis Campaign webpage
WORLD HEALTH ASSEMBLY RESOLUTION ON SEPSIS
IMPROVING THE PREVENTION, DIAGNOSIS AND MANAGEMENT OF SEPSIS
On May 26th the World Health Organisation held its 70th assembly in Geneva, Switzerland. During this gathering, 194 United Nations member states voted to affirm a resolution implementing steps to reduce the human and economic burden of sepsis. Outgoing Director-General Dr. Margaret Chan through this resolution, drew attention to these important actions:
- Publish a report on sepsis and its global consequences by the end of 2018;
- Draw attention to the public impact of sepsis;
- Collaborate with other organisations & relevant stakeholders in enhancing access to quality, safe, efficacious and affordable types of treatments of sepsis, and infection prevention and control; and
- Report to the 2020 WHA on the implementation of this resolution.
A WHO news release of the resolution is provided here along with the full resolution attached. The European Society of Intensive Care Medicine and the Society of Critical Care Medicine through the Surviving Sepsis Campaign, will be assessing steps the Campaign will take to contribute and support these vitally important efforts. Please share this resolution information amongst your colleagues at your hospital in acknowledgement that sepsis has now been officially recognised as a global challenge in which we all play an important role worldwide. Thank you all for your dedication to early identification and treatment, antibiotic stewardship and continued vigilance on behalf of the patients we serve.
Awards
Recombinant human IL-7 in the treatment of sepsis: preclinical study in patients and animal model of sepsis.
Fabienne Venet
Implication of MAIT cells and other innate-like lymphocytes in the pathophysiology of septic shock
Frédéric Pene
Suggested videos
SEPSIS: The end of EGDT?
In this icTV interview, Jean-Louis Vincent tackles this and the many other lingering questions related to the treatment and study of sepsis.
Commentary on the HYPRESS Trial
SCCM President Todd Dorman comments on the HYPRESS trial on the use of hydrocortisone for the prevention of septic shock. He highlights the strengths and limitations of this randomised controlled trial and notes several key considerations for future studies.
The results of this clinical trial were originally presented October 3rd during the President’s Session at LIVES 2016 in Milan and simultaneously published in JAMA.
Link to the article in JAMA
Visit our e-LIVES platform to see more…
Negative vs. neutral trials & future research
Never one to shy away from controversial topics, Intensive Care Medicine (ICM) Deputy Editor Anders Perner holds no punches in this interview on many of the key debates related to current and future sepsis research.
Read the related free access paper in ICM: Anders Perner et al. The intensive care medicine research agenda on septic shock. Intensive Care Med (2017) 43:1294–1305 DOI 10.1007/s00134-017-4821-1
Commentary on the DESIRE Trial
In this video, Jean-Paul Mira comments on the DESIRE trial on the use of dexmedetomidine in ventilated septic patients in intensive care. The results of this clinical trial were presented for the first time during the President’s Session at LIVES 2016 October 3rd.
Watch interview with DESIRE investigators Kyohei Miyamoto and Hitoshi Yamamura here.
Visit our e-lIVES platform to see more…
Education
Master Class
Fundamentals & Updates in Sepsis is a 2-day course for intensivists in training who seek to improve their knowledge and update their skills on diagnosis and treatment of systemic inflammation & sepsis.
This master class covers basic concepts, guidelines, resolutions and recommendations on sepsis, pathophysiology, diagnosis, initial resuscitation, source control, failing organs, antibiotics & other therapies.
This interactive session will blend theory with practice. Special attention is given to case-based discussions, workshops and problem-oriented approach.
