SIS News

Section and working groups

The Systemic Inflammation and Sepsis section is led by Ricard Ferrer-Roca and Massimo Girardis.

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Research – Research Projects

Sepsis Assessment and Identification in Low Resource Settings (SAILORS). SAILORS Study Group, ESICM, SCCM collaboration.

> Abstract

Incidence of severe sepsis and septic shock

> ICM Pulse

A one-day observational study on sepsis and septic shock carried out by ESICM and SCCM under the framework of the SSC.

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The Surviving Sepsis Campaign bundles and outcome: results from the International Multicentre Prevalence Study on Sepsis (the IMPreSS study).

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> Learn more about the  Surviving  Sepsis Campaign

Abdominal Sepsis Study: Epidemiology of Etiology and Outcome is a multinational, prospective, observational study on intra-abdominal infections (IAIs) in critically ill patients with a special emphasis on epidemiology and outcomes.

Investigate microbiology and/or drug resistance patterns. Describe physician’s antimicrobial prescription patterns. Investigate outcomes (clinical response, need for surgical revision, length of hospitalisation, and mortality).

Last update

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A genetic epidemiologic study of genetic predisposition to sepsis-related mortality and morbidity in European intensive care units.

For further information

Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort
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Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study
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Association between trends in clinical variables and outcome in intensive care patients with faecal peritonitis: analysis of the GenOSept cohort
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The trial aimed at identifying factors that determine the incidence, severity and the outcome from life-threatening infections (severe sepsis/septic shock) in patients admitted to High Dependency Units (HDUs) or Intensive Care Units (ICUs) with community acquired pneumonia (CAP) or with faecal peritonitis (FP).

Further information:

Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study

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Research – Surveys

The purpose of the GSA Sepsis Quality Measures Global Survey is to characterize the current practices related to sepsis surveillance, treatment, quality improvement, and reporting worldwide.

The survey is organized by the Global Sepsis Alliance.

The survey takes about 7 to 9 minutes, is completely anonymous, and essential to reveal how sepsis is measured and treated around the world.

>Complete the survey

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Survey of Current Sepsis Recognition & Management aimed to assess how well the 2012 Surviving Sepsis guidelines are being put into practice.

Letter published in ICM ONLINE FIRST

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Relevant research

Coopersmith, C.M. et al. Surviving Sepsis Campaign: Research priorities for sepsis and septic shock.
> Read article (Free Access)

Urayeneza, O. et al. Increasing evidence-based interventions in patients with acute infections in a resource-limited setting: a before-and-after feasibility trial in Gitwe, Rwanda. 
> Read article (Free Access)

Anders Perner et al. The intensive care medicine research agenda on septic shock.
> Read article (Free Access)

Frank Bloos et al. Effect of a multifaceted educational intervention for anti-infectious measures on sepsis mortality: a cluster randomised trial.
> Read article (Free Access)

Paul E. Marik et al. Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock – A Retrospective Before-After Study.
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Ben Andrews et al. Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension
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Flavia R. Machado et al. Trying to Improve Sepsis Care in Low-Resource Settings
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Tamara Merz et al. Impact of hyperglycemia on cystathionine-γ-lyase expression during resuscitated murine septic shock.
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SepNet Critical Care Trials Group. Incidence of severe sepsis and septic shock in German intensive care units: the prospective, multicentre INSEP study.
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Baseline thrombospondin-1 concentrations are not associated with mortality in septic patients: a single-center cohort study on the intensive care unit
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Soluble Toll-like receptor 2 is a biomarker for sepsis in critically ill patients with multi-organ failure within 12 h of ICU admission
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Neuroprotective effects of intravenous immunoglobulin are mediated through inhibition of complement activation and apoptosis in a rat model of sepsis
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Article Reviews

Polymyxin B‑immobilised haemoperfusion and mortality in critically ill adult patients with sepsis/septic shock
> Read the article review

Vitamin C & Thiamine: A cocktail that saves lives in sepsis?
> Read the article review

Acute Kidney Injury in Sepsis
> Read this article review

Fluid administration in severe sepsis and septic shock
> Read this article review

Hydrocortisone & Shock in Patients with Severe Sepsis: HYPRESS
> Read this article review

SSC Guidelines 2016: Framing better care of patients with Sepsis
> Read this article review

Sepsis-3 Criteria for In-Hospital Mortality: What’s the Prognostic Accuracy?
> Read this article review

Putting them to the test in the ICU: SOFA, SIRS & qSOFA
> Read this article review

Surviving Sepsis Campaign

The Surviving Sepsis Campaign (SSC) is a partnership of the European Society of Intensive Care Medicine and the Society of Critical Care Medicine.

Last update:

Levy, M.M., Evans, L.E. & Rhodes, A. The Surviving Sepsis Campaign Bundle: 2018 update.

Relevant information:

Surviving Sepsis Campaign webpage


On May 26th the World Health Organisation held its 70th assembly in Geneva, Switzerland. During this gathering, 194 United Nations member states voted to affirm a resolution implementing steps to reduce the human and economic burden of sepsis. Outgoing Director-General Dr. Margaret Chan through this resolution, drew attention to these important actions:

  1. Publish a report on sepsis and its global consequences by the end of 2018;
  2. Draw attention to the public impact of sepsis;
  3. Collaborate with other organisations & relevant stakeholders in enhancing access to quality, safe, efficacious and affordable types of treatments of sepsis, and infection prevention and control; and
  4. Report to the 2020 WHA on the implementation of this resolution.

A WHO news release of the resolution is provided here along with the full resolution attached. The European Society of Intensive Care Medicine and the Society of Critical Care Medicine through the Surviving Sepsis Campaign, will be assessing steps  the Campaign will take to contribute and support these vitally important efforts. Please share this resolution information amongst your colleagues at your hospital in acknowledgement that sepsis has now been officially recognised as a global challenge in which we all play an important role worldwide. Thank you all for your dedication to early identification and treatment, antibiotic stewardship and continued vigilance on behalf of the patients we serve.


Recombinant human IL-7 in the treatment of sepsis: preclinical study in patients and animal model of sepsis.
Fabienne Venet

Implication of MAIT cells and other innate-like lymphocytes in the pathophysiology of septic shock
Frédéric Pene

Suggested videos

SEPSIS: The end of EGDT?

In this icTV interview, Jean-Louis Vincent tackles this and the many other lingering questions related to the treatment and study of sepsis.

Commentary on the HYPRESS Trial

SCCM President Todd Dorman comments on the HYPRESS trial on the use of hydrocortisone for the prevention of septic shock. He highlights the strengths and limitations of this randomised controlled trial and notes several key considerations for future studies.

The results of this clinical trial were originally presented October 3rd during the President’s Session at LIVES 2016 in Milan and simultaneously published in JAMA.

Link to the article in JAMA

Visit our e-LIVES platform to see more…

Negative vs. neutral trials & future research

Never one to shy away from controversial topics, Intensive Care Medicine (ICM) Deputy Editor Anders Perner holds no punches in this interview on many of the key debates related to current and future sepsis research.

Read the related free access paper in ICM: Anders Perner et al. The intensive care medicine research agenda on septic shock. Intensive Care Med (2017) 43:1294–1305 DOI 10.1007/s00134-017-4821-1

Commentary on the DESIRE Trial 

In this video, Jean-Paul Mira comments on the DESIRE trial on the use of dexmedetomidine in ventilated septic patients in intensive care. The results of this clinical trial were presented for the first time during the President’s Session at LIVES 2016 October 3rd.

Watch interview with DESIRE investigators Kyohei Miyamoto and Hitoshi Yamamura here.

Visit our e-lIVES platform to see more…


Master Class

Fundamentals & Updates in Sepsis is a 2-day course for intensivists in training who seek to improve their knowledge and update their skills on diagnosis and treatment of systemic inflammation & sepsis.

This master class covers basic concepts, guidelines, resolutions and recommendations on sepsis, pathophysiology, diagnosis, initial resuscitation, source control, failing organs, antibiotics & other therapies.

This interactive session will blend theory with practice. Special attention is given to case-based discussions, workshops and problem-oriented approach.