Section and Project Group

The Systemic Inflammation and Sepsis section is led by Massimo Girardis and Marc Leone.

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SIS News

Latest Developments

Experts have reiterated the need to go back to the drawing board (so to speak) and re-focus on basic science with pre-clinical trials. However, one of the criticisms related to this type of sepsis research is a lack of homogeneity in animal study design.

Pre-clinical sepsis guidelines are important for ICM, they can raise awareness of sepsis and enhance the translational value of animal studies in pre-clinical trials.

Read the international expert consensus initiative for improvement of animal modelling in sepsis – Minimum quality threshold in pre-clinical sepsis studies (MATiPSS), here.

A number of important, key messages were agreed at last month’s meeting of the European Sepsis Alliance. The meeting took place in Brussels on 18 March and brought together healthcare professionals, policymakers, researchers, and industry representatives, as well as patient and family representatives. The European Sepsis Alliance calls for a joint action.

It was highlighted at the meeting that interdisciplinary action is needed to tackle sepsis because at its core it is a challenge at many levels. Sepsis is considered the most preventable cause of death and disability in Europe.

Read our report here.

Key messages:
*The inclusion of patients and families in future discussions
*The creation of a network and guidelines created by an interdisciplinary committee, e.g. intensivists, nurses, microbiologists, etc
*Creation and implementation of national strategies, taking into account countries’ specificities
*Creation of an action plan at EU-level
*Sharing of good practices among disciplines and countries
*Creation of an awareness campaign for laypersons and policymakers
*Improved training of healthcare professionals

Research – Research Projects

Sepsis Assessment and Identification in Low Resource Settings (SAILORS). SAILORS Study Group, ESICM, SCCM collaboration.

> Abstract

Incidence of severe sepsis and septic shock

> ICM Pulse

Abdominal Sepsis Study: Epidemiology of Etiology and Outcome is a multinational, prospective, observational study on intra-abdominal infections (IAIs) in critically ill patients with a special emphasis on epidemiology and outcomes.

Investigate microbiology and/or drug resistance patterns. Describe physician’s antimicrobial prescription patterns. Investigate outcomes (clinical response, need for surgical revision, length of hospitalisation, and mortality).

Last update

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The trial aimed at identifying factors that determine the incidence, severity and the outcome from life-threatening infections (severe sepsis/septic shock) in patients admitted to High Dependency Units (HDUs) or Intensive Care Units (ICUs) with community acquired pneumonia (CAP) or with faecal peritonitis (FP).

Further information:

Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study

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Research – Surveys

The purpose of the GSA Sepsis Quality Measures Global Survey is to characterize the current practices related to sepsis surveillance, treatment, quality improvement, and reporting worldwide.

The survey is organized by the Global Sepsis Alliance.

The survey takes about 7 to 9 minutes, is completely anonymous, and essential to reveal how sepsis is measured and treated around the world.

>Complete the survey

>Learn more

Relevant research

Marcin F. Osuchowski et al. Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis.
> Read article

Coopersmith, C.M. et al. Surviving Sepsis Campaign: Research priorities for sepsis and septic shock.
> Read article

Urayeneza, O. et al. Increasing evidence-based interventions in patients with acute infections in a resource-limited setting: a before-and-after feasibility trial in Gitwe, Rwanda. 
> Read article

Anders Perner et al. The intensive care medicine research agenda on septic shock.
> Read article

Frank Bloos et al. Effect of a multifaceted educational intervention for anti-infectious measures on sepsis mortality: a cluster randomised trial.
> Read article

Article Reviews

Continuous Haemodynamic Monitoring with a Transesophageal echocardiography probe in patients with shock
> Read the article review

Polymyxin B‑immobilised haemoperfusion and mortality in critically ill adult patients with sepsis/septic shock
> Read the article review

Vitamin C & Thiamine: A cocktail that saves lives in sepsis?
> Read the article review

Acute Kidney Injury in Sepsis
> Read this article review

Fluid administration in severe sepsis and septic shock
> Read this article review

Surviving Sepsis Campaign

The Surviving Sepsis Campaign (SSC) is a partnership of the European Society of Intensive Care Medicine and the Society of Critical Care Medicine.

Last update:

Levy, M.M., Evans, L.E. & Rhodes, A. The Surviving Sepsis Campaign Bundle: 2018 update.

Relevant information:

Surviving Sepsis Campaign webpage


On May 26th the World Health Organisation held its 70th assembly in Geneva, Switzerland. During this gathering, 194 United Nations member states voted to affirm a resolution implementing steps to reduce the human and economic burden of sepsis. Outgoing Director-General Dr. Margaret Chan through this resolution, drew attention to these important actions:

  1. Publish a report on sepsis and its global consequences by the end of 2018;
  2. Draw attention to the public impact of sepsis;
  3. Collaborate with other organisations & relevant stakeholders in enhancing access to quality, safe, efficacious and affordable types of treatments of sepsis, and infection prevention and control; and
  4. Report to the 2020 WHA on the implementation of this resolution.

A WHO news release of the resolution is provided here along with the full resolution attached. The European Society of Intensive Care Medicine and the Society of Critical Care Medicine through the Surviving Sepsis Campaign, will be assessing steps  the Campaign will take to contribute and support these vitally important efforts. Please share this resolution information amongst your colleagues at your hospital in acknowledgement that sepsis has now been officially recognised as a global challenge in which we all play an important role worldwide. Thank you all for your dedication to early identification and treatment, antibiotic stewardship and continued vigilance on behalf of the patients we serve.


Recombinant human IL-7 in the treatment of sepsis: preclinical study in patients and animal model of sepsis.
Fabienne Venet

Implication of MAIT cells and other innate-like lymphocytes in the pathophysiology of septic shock
Frédéric Pene


Master Class

Sepsis and Severe Infections is a 2-day course for intensivists in training who seek to improve their knowledge and update their skills on diagnosis and treatment of systemic inflammation & sepsis.

This master class covers basic concepts, guidelines, resolutions and recommendations on sepsis, pathophysiology, diagnosis, initial resuscitation, source control, failing organs, antibiotics & other therapies.

This interactive session will blend theory with practice. Special attention is given to case-based discussions, workshops and problem-oriented approach.


Free live webinars are available for members & non members on the ESICM Media Library.