Section and Section Project Groups

The Acute Respiratory Failure (ARF) section is led by Luigi Camporota and Lise Piquilloud.

Project Groups :

  • ECMO Project Group: Michael Quintel
    > To examine the indications for extracorporeal technologies [ECMO. Extracorporeal CO2 removal, etc]
  • Pneumonia Project Group: Head Maria Deja
    Last meeting minutes (Berlin, October 1st, 2019).

> Learn more about this section

ARF News

Research – Research Projects

APRONET is a ONE-day prevalence study initiated by the ESICM Acute Respiratory Failure Section (ARF), which will be repeated four times during a one year period. It is a multicentre observational prospective study with no patient follow-up.


Prone position is used in almost 14% of severe ARDS patients according to the results of the LUNG-SAFE study. This rate is rather low given the results of the most recent trial that showed a beneficial effect of proning on patient outcome, a finding which is in line with previous meta-analyses. The reasons why the use of proning is still limited are unclear.

> Read more

WorldwidE AssessmeNt of Separation of pAtients From ventilatory assistancE is a multi-centre, prospective, observational, 4-week inception cohort study being carried out by the Acute Respiratory Failure section of ESICM.


Weaning represents a challenge for intensivists and patients spend a considerable amount of time in being liberated from mechanical ventilation. While guidelines do exist on the classification of weaning, a recent study has shown that these may not be applicable to all patients.

Read More

A Strategy of UltraProtective lung ventilation With Extracorporeal CO2 Removal for New-Onset moderate to seVere ARDS. It was a pilot trial; a feasibility and safety trial

This study will assess changes in pH/ PaO2 /PaCO2, Respiratory Rate and device CO2 clearance in the first 24 hours of ECCO2R following VT and plateau pressure reduction in patients with moderate ARDS. Safety variables during treatment will also be analysed.

Read More

Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE is a multicentre, prospective, observational, 4-week inception cohort study, which has been carried out by the Acute Respiratory Failure section through the ESICM Trials Group.

The study aimed to prospectively assess the burden of, management and therapeutic approaches to, and outcomes from acute hypoxaemic respiratory failure requiring ventilatory support, with a specific focus on ARDS as defined by the Berlin Definition.

Read More

Weaning from mechanical ventilation: comparison of open-loop decision support system and routine care, in general medical ICU

The aim of this project is to perform an international multicentre prospective observational cohort study of nosocomial pneumonia in intensive care units (ICUs) worldwide in order to provide up-to-date and comprehensive descriptive data on the diagnosis, microbiology, time course of resolution, management and outcomes in a global ICU population.

PRessuresuppOrTvEntilation + sigh in aCuTehypoxemIcrespiratOry failure patieNts. This study, initiated within the ESICM PLUG Working Group, is a randomised controlled on the effects of short cyclic recruitment maneuver  added to pressure support ventilation that will be conducted in several ICUs in different countries

Incidence of dysynchronous spontaneous Breathing Effort, breath-stacking and reverse triggering in early ARDS

This project, initiated by the ESICM PLUG (Pleural Pressure) Working Group, is an observational multicentre physiological study that will be conducted in several ICUs in different countries.

Research – Surveys

The survey aims at assessing the practice of the use of the automatic tube compensation (ATC) option, which is available in several ICU ventilators

Contact: Prof. Dr. Claude Guérin

Completing this survey will only take you less than 5 minutes. Your responses will be kept confidential.

Complete the survey, here

TrainECMO Survey on packed red blood cells transfusion practice in vv-Ecmo patients. Mortality associated with Acute Respiratory Distress Syndrome (ARDS) remains high, despite continual improvement in mechanical ventilation and extracorporeal membrane oxygenation (ECMO).

Technical simplifications, and its use during the 2009 H1N1 influenza pandemic, prompted a sharp increase in the use of ECMO worldwide.

Publication: Martucci et al. Hemoglobin trigger and approach to red blood cell transfusions during veno-venous extracorporeal membrane oxygenation: the international TRAIN-ECMO survey

To evaluate the most common practice on tracheostomy and to build a snapshot about tracheostomy techniques and finally to underline the differences among European countries on this topic.

CHANGE IT! State of the art on paediatric and neonatal lung/heart transplantation in Europe.

This survey from the ESPNIC Respiratory Section and endorsed by ESICM.

Contact: Daniele De Luca

The survey aims to assess the current state of paediatric (<12 m old) and neonatal lung (or heart/lung) transplantation including physicians’ awareness knowledge across Europe.

Relevant research

Claude Guérin et al. A prospective international observational prevalence study on prone positioning of ARDS patients: the APRONET (ARDS Prone Position Network) study.
> Read article (Free Access)

Alain Combes et al. The ICM research agenda on extracorporeal life support.
> Read article (Free Access)

Samir Jaber et al. The intensive care medicine research agenda for airways, invasive and noninvasive mechanical ventilation.
> Read article (Free Access)

Cambiaghi B et al. Effects of regional perfusion block in healthy and injured lungs.
> Read article (OPEN ACCESS)

Fan E et al. Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome.
> Read more

Severe hypercapnia and outcome of mechanically ventilated patients with moderate or severe Acute Respiratory Distress Syndrome.
> Read more

High Flow Nasal Cannula (HFNC) versus nasal continuous positive airway pressure (nCPAP) for the initial respiratory management of acute viral bronchiolitis in young infants: a multi-centre randomised controlled trial (TRAMONTANE study).
> Read more

Assessment of heart rate, acidosis, consciousness, oxygenation, and respiratory rate to predict non-invasive ventilation failure in hypoxemic patients.
> Read more

Article Reviews

Want to reduce reintubation rates? Reconnect to Mechanical Ventilation for 1h after a successful spontaneous breathing trial
> Read the article review


Headspace analysis of airway fluid samples for the prediction of ventilator-acquired pneumonia.

Lieuwe Bos

Haemodynamic effect of lung function optimisation in Acute Respiratory Distress Syndrome (HEARDS).

Arnaldo Santos Oviedo

Prospective, Randomized, Multi-Center Trial of Lateral Trendelenburg versus Semi- Recumbent Body Position in Mechanically Ventilated Patients For The Prevention of Ventilator-Associated Pneumonia

Mauro Panigada

PRessure suppOrT vEntilation + sigh in hypoxemiC acuTe respIratOry failure patieNts (PROTECTION): a pilot pragmatic randomized controlled trial

Tommaso Mauri



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