Abdominal Sepsis Study: Epidemiology of Etiology and Outcome



AbSeS (Abdominal Sepsis Study: Epidemiology of Etiology and Outcome) is a multinational, prospective, observational study on intra-abdominal infections (IAIs) in critically ill patients with a special emphasis on epidemiology and outcomes.


The specific objectives of this study are:

  • To investigate microbiology and/or drug resistance patterns related to:
    • Geographical region
    • Source of IAI
    • Origin of IAI
  • To describe physician’s antimicrobial prescription patterns related to a classification grid that stratifies IAIs according to disease expression, community or healthcare origin, and anatomical disruption.
  • To investigate outcomes (clinical response, need for surgical revision, length of hospitalisation, and mortality) related to:
    • Type of IAI
    • Severity of acute illness at time of diagnosis (SOFA score) and clinical response after 48-72 hrs
    • Processes of care
    • Pathogens involved and empirical antimicrobial coverage; special emphasis will be given, to coverage of multidrug resistant Enterobacteriaceae, Pseudomonas aeruginosa, enterococci and Candida species
    • Duration of antimicrobial therapy


Data collection began on 1st January and  has been completed on 31 December 2016.


K. Arvaniti, G. Dimopoulos, M. Antonelli et al., Epidemiology and age-related mortality in critically ill patients with intra-abdominal infection or sepsis: an international cohort study, International Journal of Antimicrobial Agents; article in press on May 21, 2022: https://doi.org/10.1016/j.ijantimicag.2022.106591.
Dirk VogelaersStijn BlotAndries Van den BergePhilippe MontraversAbdominal Sepsis Study (‘AbSeS’) Group on behalf of the Trials Group of the Europan Society f Intensive Care Medicine Antimircrobial Lessons From a Large Observational Cohort on Intra-abdominal Infections in Intensive Care Units Drugs,  2021 Jun;81(9):1065-1078.  doi: 10.1007/s40265-021-01534-w. Epub 2021 May 26.

The primary paper: Blot S, Antonelli M, Arvaniti K, Blot K, Creagh-Brown B, de Lange D, et al. Epidemiology of intra-abdominal infection and sepsis in critically ill patients: “AbSeS”, a multinational observational cohort study and ESICM Trials Group Project. Intensive Care Medicine volume 45, pages 1703–1717 (2019)PubMed – PMC


• AbSeS Steering Committee

Protocol & CRF

National Coordinators

Data Ownership

• PRS Number


For more information, please contact research@esicm.org