Abdominal Sepsis Study: Epidemiology of Etiology and Outcome

Q&A

What?

AbSeS (Abdominal Sepsis Study: Epidemiology of Etiology and Outcome) is a multinational, prospective, observational study on intra-abdominal infections (IAIs) in critically ill patients with a special emphasis on epidemiology and outcomes.

Why?

The specific objectives of this study are:

• To investigate microbiology and/or drug resistance patterns related to:
  • Geographical region
  • Source of IAI
  • Origin of IAI
• To describe physician’s antimicrobial prescription patterns related to a classification grid that stratifies IAIs according to disease expression, community or healthcare origin, and anatomical disruption.
• To investigate outcomes (clinical response, need for surgical revision, length of hospitalisation, and mortality) related to:
  • Type of IAI
  • Severity of acute illness at time of diagnosis (SOFA score) and clinical response after 48-72 hrs
  • Processes of care
  • Pathogens involved and empirical antimicrobial coverage; special emphasis will be given, to coverage of multidrug resistant Enterobacteriaceae, Pseudomonas aeruginosa, enterococci and Candida species
  • Duration of antimicrobial therapy

When?

Data collection began on 1st January and  has been completed on 31 December 2016.

Publications

K. Arvaniti, G. Dimopoulos, M. Antonelli et al., Epidemiology and age-related mortality in critically ill patients with intra-abdominal infection or sepsis: an international cohort study, International Journal of Antimicrobial Agents; article in press on May 21, 2022: https://doi.org/10.1016/j.ijantimicag.2022.106591.

Dirk Vogelaers, Stijn Blot,  Andries Van den Berge, Philippe Montravers, Abdominal Sepsis Study (‘AbSeS’) Group on behalf of the Trials Group of the Europan Society f Intensive Care Medicine Antimircrobial Lessons From a Large Observational Cohort on Intra-abdominal Infections in Intensive Care Units Drugs,  2021 Jun;81(9):1065-1078.  doi: 10.1007/s40265-021-01534-w. Epub 2021 May 26.

The primary paper: Blot S, Antonelli M, Arvaniti K, Blot K, Creagh-Brown B, de Lange D, et al. Epidemiology of intra-abdominal infection and sepsis in critically ill patients: “AbSeS”, a multinational observational cohort study and ESICM Trials Group Project. Intensive Care Medicine volume 45, pages 1703–1717 (2019) – PubMed – PMC

Documents

• AbSeS Steering Committee
• Protocol & CRF
• National Coordinators
• Data Ownership
• PRS Number

Contact

For more information, please contact research@esicm.org