Abdominal Sepsis Study: Epidemiology of Etiology and Outcome
AbSeS (Abdominal Sepsis Study: Epidemiology of Etiology and Outcome) is a multinational, prospective, observational study on intra-abdominal infections (IAIs) in critically ill patients with a special emphasis on epidemiology and outcomes.
The specific objectives of this study are:
- To investigate microbiology and/or drug resistance patterns related to:
- Geographical region
- Source of IAI
- Origin of IAI
- To describe physician’s antimicrobial prescription patterns related to a classification grid that stratifies IAIs according to disease expression, community or healthcare origin, and anatomical disruption.
- To investigate outcomes (clinical response, need for surgical revision, length of hospitalisation, and mortality) related to:
- Type of IAI
- Severity of acute illness at time of diagnosis (SOFA score) and clinical response after 48-72 hrs
- Processes of care
- Pathogens involved and empirical antimicrobial coverage; special emphasis will be given, to coverage of multidrug resistant Enterobacteriaceae, Pseudomonas aeruginosa, enterococci and Candida species
- Duration of antimicrobial therapy
Data collection began on 1st January and has been completed on 31 December 2016.
The primary paper: Blot S, Antonelli M, Arvaniti K, Blot K, Creagh-Brown B, de Lange D, et al. Epidemiology of intra-abdominal infection and sepsis in critically ill patients: “AbSeS”, a multinational observational cohort study and ESICM Trials Group Project. Intensive Care Medicine volume 45, pages 1703–1717 (2019) – PubMed – PMC
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