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Research – Trials

A multicentre, placebo-controlled double-blind phase III randomised clinical trial to examine the effect of high-dose vitamin D3 on 28-day mortality in adult critically ill patients with severe vitamin D deficiency

To date, only 7 interventions (e.g. noninvasive ventilation, pronepositioning…) have demonstrated a mortality benefit for ICU patients in multicentre trials. If proven to be beneficial, vitamin D treatment in critically ill patients could be immediately implemented worldwide.

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Intestinal-Specific Organ Function Assessment. To prospectively evaluate the value of gastrointestinal symptoms alone and in combination with intra-abdominal pressure (IAP), and acute gastrointestinal injury (AGI) grades

To determine whether biochemical markers (plasma and urine) of intestinal injury are of additional prognostic value compared to clinical gastro-intestinal symptoms and AGI grades.

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Prospective, observational, multicentre study of gastrointestinal dysfunction in critically-ill patients. Development of gastrointestinal failure score

Publication:

Gastrointestinal symptoms during the first week of intensive care are associated with poor outcome: a prospective multicentre study.

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The specific aim of this project is to assess nutritional therapy in ICUs on a specific date in order to detect correlations between nutritional therapies and outcome based on a large European sample.
https://www.nutritionday.org/

Publications:

NutritionDay in Nursing Homes – The Association of Nutritional Intake and Nutritional Interventions With 6-Month Mortality in Malnourished Residents.
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NutritionDay: 10 years of growth
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Comparative effects of two glucose control regiments by insulin in ICU patients. This project, which is now over, aimed at defining whether a tight glucose control by insulin improved the vital outcome in a mixed population of critically-ill patients.

Publications:

A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study.
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Glucontrol, no control, or out of control?
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Relevant research

Yaseen M. Arabi et al. The intensive care medicine research agenda in nutrition and metabolism.
> Read article (Free Access)

Annane D et al. Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part I)
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Yaseen M. Arabi and Jean-Charles Preiser, A critical view on primary and secondary outcome measures in nutrition trials.
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François Bagate et al. Association between relative adrenal insufficiency and septic cardiomyopathy: a preliminary report.
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Matteo Bassetti et al. Antimicrobial resistance in the next 30 years, humankind, bugs and drugs: a visionary approach.
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Gennaro Martucci et al. The effect of high-dose cholecalciferol on bioavailable vitamin D levels in critically ill patients: a post hoc analysis of the VITdAL-ICU trial.
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Article Reviews

IRON supplementation in ICU patients: The IRONMAN Trial
> Read this article review

Abnormal liver tests in ICU patients: What do they really signal?
> Read this article review

NICE-SUGAR: Glucose Control in Traumatic Brain Injury
> Read this article review

Nutrition in the acute phase of critical illness: Recent findings
> Read this article review

Feeding critically ill trauma patients: Searching for the perfect alchemy
> Read this article review

Suggested talks

Are humans capable of modulating their immune response at will?

icTV sits down with Peter Pickkers to discuss his fascinating study which attempted to challenge the belief that the autonomic nervous and immune systems cannot be voluntarily influenced by utilising a short-term training programme, consisting of meditation, breathing techniques and cold exposure.

Peter Pickkers was a keynote speaker at LIVES 2015, ESICM’s 28th Annual Congress in Berlin. See his full presentation at LIVES in e-LIVES.

Visit our e-LIVES platform to see more…

bouton-e-lives

RCT ‘CALORIES’ RESULTS

In this interview, Kathy Rowan reveals results from the CALORIES trial which compared early nutritional support with parenteral versus enteral routes. She also shares her thoughts on the clinical impact of the results and provides details about the next steps. These results were presented at the Hot Topics Session at LIVES 2014 in Barcelona and simultaneously published in NEJM.

RCT ‘CALORIES’ RESULTS : full presentation

Watch the full presentation.

Education

Webinar ~ Acute on chronic liver failure

Webinar ~ IV iron: A solution for anaemia in intensive care?

> Watch Replay