Section and Project Group

The Metabolism, Endocrinology & Nutrition section is led by Mette M. Berger and Gunnar Elke.

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Research – Research Projects

A multicentre, placebo-controlled double-blind phase III randomised clinical trial to examine the effect of high-dose vitamin D3 on 28-day mortality in adult critically ill patients with severe vitamin D deficiency

To date, only 7 interventions (e.g. non invasive ventilation, prone positioning…) have demonstrated a mortality benefit for ICU patients in multicentre trials. If proven to be beneficial, vitamin D treatment in critically ill patients could be immediately implemented worldwide.

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Intestinal-Specific Organ Function Assessment. To prospectively evaluate the value of gastrointestinal symptoms alone and in combination with Intra-Abdominal Pressure (IAP), and Acute Gastrointestinal Injury (AGI) grades

To determine whether biochemical markers (plasma and urine) of intestinal injury are of additional prognostic value compared to clinical gastro-intestinal symptoms and AGI grades.

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Prospective, observational, multicentre study of gastrointestinal dysfunction in critically-ill patients. Development of gastrointestinal failure score

Publication:

Gastrointestinal symptoms during the first week of intensive care are associated with poor outcome: a prospective multicentre study.

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The specific aim of this project is to assess nutritional therapy in ICUs on a specific date in order to detect correlations between nutritional therapies and outcome based on a large European sample.
https://www.nutritionday.org/

Publications:

NutritionDay in Nursing Homes – The Association of Nutritional Intake and Nutritional Interventions With 6-Month Mortality in Malnourished Residents.
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NutritionDay: 10 years of growth
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Comparative effects of two glucose control regiments by insulin in ICU patients. This project, which is now over, aimed at defining whether a tight glucose control by insulin improved the vital outcome in a mixed population of critically-ill patients.

Publications:

A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study.
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Glucontrol, no control, or out of control?
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Relevant research

Yaseen M. Arabi et al. The intensive care medicine research agenda in nutrition and metabolism.
> Read article (Free Access)

Annane D et al. Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part I)
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Yaseen M. Arabi and Jean-Charles Preiser, A critical view on primary and secondary outcome measures in nutrition trials.
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François Bagate et al. Association between relative adrenal insufficiency and septic cardiomyopathy: a preliminary report.
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Matteo Bassetti et al. Antimicrobial resistance in the next 30 years, humankind, bugs and drugs: a visionary approach.
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Gennaro Martucci et al. The effect of high-dose cholecalciferol on bioavailable vitamin D levels in critically ill patients: a post hoc analysis of the VITdAL-ICU trial.
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Article Reviews

Pantoprazole prophylaxis in ICU patients with high severity of disease
> Read this article review

IRON supplementation in ICU patients: The IRONMAN Trial
> Read this article review

Abnormal liver tests in ICU patients: What do they really signal?
> Read this article review

NICE-SUGAR: Glucose Control in Traumatic Brain Injury
> Read this article review

Nutrition in the acute phase of critical illness: Recent findings
> Read this article review

Education

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