The Translational biology section is led by John Laffey.

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The mission of the Translational Biology Section is to advance the care of critically ill patients by discovering and advancing new and emerging therapies towards clinical testing. The Section will enable its members to discover novel pathways, biomarkers and interventions in critical illness that can then be tested in clinical trials to discover new therapies for our patients.

Specific Initiatives

The Translational biology Section was founded in 2017 as a Group within the Acute Respiratory Failure section, and so has progressed a number of initiatives, including the following:

  • Creating a Registry of Basic/Translational research groups that are happy to share information and collaborate
  • Contributing to Basic/Translational science sessions at LIVES conferences,
  • Partnering with Intensive Care Medicine Experimental to develop and publish ‘viewpoint’ and ‘position’ papers relating to preclinical research and its importance in Intensive Care Medicine.
  • Partnering with the INSPIRES group (a group of lung researchers in Europe) to provide a platform for presentation of preclinical/translational research that focuses on emerging researchers.
  • Partnering with the NEXT trainee group to examine ways to provide enhanced training opportunities using our network of laboratories across Europe.

Recent examples of the scientific outputs of the section include

Nicole P Juffermans, Peter Radermacher, John G Laffey , Translational Biology Group. The importance of discovery science in the development of therapies for the critically ill. Intensive Care Medicine Experimental, 2020
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Adrien Carla, Bruno Pereira, Hanifa Boukail et al. ESICM Translational Biology Group of the Acute Respiratory Failure section. Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis. Respiratory Research, 2020
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Nicole P Juffermans, Marcus Schultz, Lieuwe D Bos, Oscar Penuelas, John Laffey , Jose A Lorente. Why translational research matters: proceedings of the third international symposium on acute lung injury translational research (INSPIRES III). Intensive Care Medicine Experimental, 2019
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