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AKI Section

The Acute Kidney Injury section is led by Eric Hoste and Marlies Ostermann.

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Research – Trials

PEACE is an ESICM prospective international, multi-centre, prevalence study on the epidemiology of the use of renal replacement therapy for ICU patients who have acute kidney injury and chronic end stage kidney disease.

The purpose of this study is to provide new and current data on both the disease burden of acute kidney injury requiring renal replacement therapy as well modalities used.

 

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Aim
To determine whether, in critically ill patients with severe acute kidney injury (AKI), a strategy of accelerated (early) initiation of renal replacement therapy (RRT), compared to a standard (delayed) strategy for initiation of RRT contributes to improved 90-day survival and recovery of kidney function.  

Design
Multi-national, multicentre, open-label, randomised, controlled trial. The trial is currently enrolling participants in 6 countries at 44 sites. The trial anticipates a total of 14 countries and approximately 100 sites.

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Epidemiologic Prospective Investigation

The aim of the study is to evaluate the epidemiology and early management of acute kidney injury, according to the RIFLE classification in ICU patients.

Further information can be found at www.akinet.org.

Eric Hoste Interview

In this icTV interview, we sit down with Eric Hoste, to discuss the AKI-EPI study – one of the most accessed articles in Intensive Care Medicine in 2015/2016.

Read the article in ICM

Research – Surveys

The Initiation of Renal Replacement Therapy in the ICU Survey (IRIS). The aim of this survey was to gain insights into the way intensivists prescribe RRT in the ICU with a special focus on the criteria they choose to initiate RRT.

Relevant Research

Meersch M, Schmidt C, Hoffmeier A, et al. Prevention of cardiac surgery-associated AKI by implementing the KDIGO guidelines in high risk patients identified by biomarkers: the PrevAKI randomised controlled trial.
> Read More (Free Access)

Peter Pickkers et al. The intensive care medicine agenda on acute kidney injury
> Read More (Free Access)

Thiago Gomes Romano et al. Effect of continuous dialysis on blood pH in acidemic hypercapnic animals with severe acute kidney injury: a randomised experimental study comparing high vs. low bicarbonate affluent
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Hans Flaatten and Michael Darmon. A nephrologist should be consulted in all cases of acute kidney injury in the ICU: yes
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John A. Kellum and Eric A. J. Hoste. A nephrologist should be consulted in all cases of acute kidney injury in the ICU: No
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Frederik H. Verbrugge et al. Diuretics in cardiorenal syndrome: what’s new?
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Antoine Schneider et al. What’s new: prevention of acute dialysis catheter-related infection
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Article Reviews

Can KDIGO panel guidelines prevent cardiac surgery-associated AKI?
> Read the article review (Free Access)

Suggested talks

Renal Replacement Therapy: What controversies remain?

Clinicians are always seeking the “optimal” treatment strategy…
In this icTV interview, expert John Kellum addresses this holy grail-type search when it comes to renal replacement therapy and he pinpoints what we know about this therapy at the bedside, and the controversies that still remain.

Visit our e-LIVES platform to see more…

bouton-e-lives

Effects of remote ischaemic preconditioning in cardiac surgery patients

In this icTV interview, Alexander Zarbock (Münster, Germany) discusses his follow-up randomised clinical trial on the long term effects of remote ischaemic preconditioning in high-risk AKI patients undergoing cardiac surgery.

Visit our e-LIVES platform to see more…

bouton-e-lives

Key Treatment Guidelines
for Hyponatraemia

In this icTV interview, Michael Joannidis, one of the authors of the recently published guidelines on diagnosis and treatment of hyponatraemia outlines the rationale for the creation of the guidelines – the first ever on this complex condition He also highlights several key strategies for clinicians when this treatment is suspected and zeroes in on future options in management of hyponatraemia.

Read more news on the release of the guidelines here.

Read the guidelines in Intensive Care Medicine (open access) here.

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Education – webinars