Peripheral oxygenation targets in critically ill children: Pilot Oxy-PICU definitive trial

Feasibility of a definitive trial of peripheral oxygenation targets in critically ill children: pilot Oxy-PICU trial EJRC Article Review Although peripheral oxygen saturation (SpO2) monitoring is universal, the optimum target for ventilated critically ill children is uncertain. Lower SpO2targets at 85-89% is favoured in preterm infants [1]. In adults, reported mean number needed to harm […]

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How accurate are predictive outcomes for ventilator-associated events?

How accurate are predictive outcomes for ventilator-associated events? Results from the EUVAE study In 2013, the Centre for Disease Control and Prevention (CDC) proposed (and in 2015 updated) a new diagnostic algorithm for ventilator-associated events (VAEs) based on more objective criteria and easily measurable clinical features [1,2]. The algorithm divides the causes of respiratory worsening in […]

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Augmented renal clearance: Impact on continuously infused TZP concentrations?

Does augmented renal clearance have a negative impact on continuously infused TZP concentrations? EJRC Article Review Inappropriate antibiotic dosing has been linked to adverse infection outcomes1,2. Augmented renal clearance (ARC, >130mL/min) has been identified as a risk factor for low beta-lactam antibiotic concentrations in ICU patients 5,6. Because beta-lactam antibiotics have time-dependent killing properties, prolonging […]

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Ventilator-associated complications in patients with ESBLE infections

Ventilator-associated complications in patients with ESBLE infections EJRC Article Review   Extended-spectrum b-lactamase producing Enterobacteriaceae (ESBLE) colonise a growing proportion of critically ill patients in the intensive care unit (ICU)[1]. ESBLE colonisation is an established risk factor for subsequent infections [2]. Although guidelines suggest to consider the colonisation status of patients to adjust empirical treatment […]

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