Impact of real-time TDM on the prescription of antibiotics in burn patients

EJRC Article Review Patients with burn injuries may experience marked pharmacokinetic (PK) changes compared to healthy volunteers and patients admitted without burn injuries. These PK changes are related to both specific pathophysiologic alterations and the frequent use of supportive therapy in burn injury patients. Therefore, achieving adequate antibiotic drug concentrations in burn patients is challenging1. […]

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What is the real impact of no sedation during mechanical ventilation?

What is the real impact of no sedation during mechanical ventilation? EJRC ARTICLE REVIEW   For many years, standard therapy for patients undergoing mechanical ventilation included sedation. It was seen as a way to ease patients and help them to accept the procedure. In the last decade, randomised controlled trials (RCTs) have shown that utilising […]

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Are SOFA, SIRS, PELOD-2, and qSOFA accurate outcome predictors in children?

EJRC Article Review   Paediatric sepsis definitions are based upon expert consensus from the International Paediatric Sepsis Consensus Conference [1]. The adult Sepsis-3 update on definitions has changed how patients with sepsis are identified, thus impacting on the research and quality indicators associated with its management [2]. Schlapbach et al. compared the performance of SIRS, […]

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Reviving glucocorticoids to treat Sepsis?

Reviving glucocorticoids to treat Sepsis? EJRC Article Review   Certainly, one of the greatest calamities of the modern world is Sepsis, which, despite the great advances in medicine, still doesn’t have a specific pharmacological treatment. This could be explained by the nature of Sepsis, as a very complex pathological entity, capable of affecting multiple organs, […]

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ICUs in 2050: What end-of-life communication challenges await us?

ICUs in 2050: What end-of-life communication challenges await us? EJRC ARTICLE REVIEW   A paper in the “Intensive care medicine in 2050” article series published in recent months in Intensive Care Medicine, highlights how social and technological evolutions may have an impact on our way of communicating on end of life issues in the future […]

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Pressure injuries and sedation: Are they related?

Pressure injuries and sedation: Are they related?  EJRC ARTICLE REVIEW Critically ill patients inherently have most of the risk factors for the development of pressure injuries. One of the key factors is immobility, which is very frequent in ICUs. This lack of mobility is enhanced by the administration of sedation and a decreased consciousness of […]

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