Augmented renal clearance: Impact on continuously infused TZP concentrations?

Does augmented renal clearance have a negative impact on continuously infused TZP concentrations? EJRC Article Review Inappropriate antibiotic dosing has been linked to adverse infection outcomes1,2. Augmented renal clearance (ARC, >130mL/min) has been identified as a risk factor for low beta-lactam antibiotic concentrations in ICU patients 5,6. Because beta-lactam antibiotics have time-dependent killing properties, prolonging […]

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Ventilator-associated complications in patients with ESBLE infections

Ventilator-associated complications in patients with ESBLE infections EJRC Article Review   Extended-spectrum b-lactamase producing Enterobacteriaceae (ESBLE) colonise a growing proportion of critically ill patients in the intensive care unit (ICU)[1]. ESBLE colonisation is an established risk factor for subsequent infections [2]. Although guidelines suggest to consider the colonisation status of patients to adjust empirical treatment […]

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Is Trimodulin a safe and beneficial adjuvant therapy for adult patients with sCAP?

Is Trimodulin a safe and beneficial adjuvant therapy for adult patients with sCAP? EJRC Article Review Severe community-acquired pneumonia (sCAP) remains associated with high mortality despite widespread use of supportive care and targeted antibiotic therapy. Evidence suggests that IgM-enriched Immunoglobulin preparations are associated with a decrease in mortality in severe sepsis and septic shock. In […]

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ICM THIS WEEK ~ ONLINE FIRST articles

ONLINE FIRST (FREE ACCESS) Editorial ~ Martin J. Tobin. Conflicts of interest and the patient–doctor covenant. Letter ~ Lama H. Nazer – Critical care research in the World Health Organisation Eastern Mediterranean Region over two decades: where do we stand? Editorial Debate ~ John A. Myburgh. Intracranial pressure thresholds in severe traumatic brain injury: Pro. Editorial Debate ~ Raimund Helbok […]

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ICM ~ New SSC papers released & ONLINE FIRST this week

New SSC papers released & ONLINE FIRST this week Intensive Care Medicine (ICM) We are delighted to announce the release of two pivotal papers focused on the Surviving Sepsis Campaign (SSC) this week: Surviving Sepsis Campaign: Research priorities for sepsis and septic shock Increasing evidence-based interventions in patients with acute infections in a resource-limited setting: […]

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ICM ~ ONLINE FIRST this week

ONLINE FIRST (FREE ACCESS)   ​From the Inside ~ Nicola Petrucci et al. Beyond bleeps and alarms: live music by the bedside in the ICU. Systematic Review ~ Sarah Vollam et al. Out-of-hours discharge from intensive care, in-hospital mortality and intensive care readmission rates: a systematic review and meta-analysis. Understanding the Disease ~ Pierre Tattevin et […]

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