How accurate are predictive outcomes for ventilator-associated events?

How accurate are predictive outcomes for ventilator-associated events? Results from the EUVAE study In 2013, the Centre for Disease Control and Prevention (CDC) proposed (and in 2015 updated) a new diagnostic algorithm for ventilator-associated events (VAEs) based on more objective criteria and easily measurable clinical features [1,2]. The algorithm divides the causes of respiratory worsening in […]

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THE HOTTEST TRIALS RESULTS IN ICM: Videos & links!

HOT TOPICS SESSION Wednesday October 24th #LIVES2018      With eight scientific trials, presented for the first time, this highly anticipated Hot Topics session is sure to generate some discussion across the field. Papers from several trials in this session will be simultaneously published in major medical journals and results have been embargoed until the session begins… […]

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Augmented renal clearance: Impact on continuously infused TZP concentrations?

Does augmented renal clearance have a negative impact on continuously infused TZP concentrations? EJRC Article Review Inappropriate antibiotic dosing has been linked to adverse infection outcomes1,2. Augmented renal clearance (ARC, >130mL/min) has been identified as a risk factor for low beta-lactam antibiotic concentrations in ICU patients 5,6. Because beta-lactam antibiotics have time-dependent killing properties, prolonging […]

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Ventilator-associated complications in patients with ESBLE infections

Ventilator-associated complications in patients with ESBLE infections EJRC Article Review   Extended-spectrum b-lactamase producing Enterobacteriaceae (ESBLE) colonise a growing proportion of critically ill patients in the intensive care unit (ICU)[1]. ESBLE colonisation is an established risk factor for subsequent infections [2]. Although guidelines suggest to consider the colonisation status of patients to adjust empirical treatment […]

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