ONLINE FIRST (FREE ACCESS) Original ~ Fabiana Madotto et al. Resolved versus confirmed ARDS after 24h: Insights from the LUNG SAFE study. Seven-Day Profile Publication ~ Tobias Welte et al. Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomised, placebo-controlled, double-blind, multicentre, phase II trial (CIGMA study). […]
EJRC Article Review In the last 3 years, a number of randomised controlled trials[1-6] (MR CLEAN, ESCAPE, REVASCAT, SWIFT PRIME, DEFUSE 3 and EXTEND IA) and two meta-analyses[7,8] have explored the effect of mechanical, endovascular interventions versus or added to standard treatment. These recent trials focused on larger vessels pathologies, patients with less extensive brain […]
What do we need to fight MDR infections in our patients? In this icTV video, Matteo Bassetti discusses his thoughts on where we are in regards to treatment of multi-drug resistant infections in critically ill patients. Find out more about MDR in the paper from Intensive Care Medicine (ICM): The intensive care medicine research agenda on multi-drug […]
ONLINE FIRST ~ June 10th, 2016
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EJRC Article Review Patients with burn injuries may experience marked pharmacokinetic (PK) changes compared to healthy volunteers and patients admitted without burn injuries. These PK changes are related to both specific pathophysiologic alterations and the frequent use of supportive therapy in burn injury patients. Therefore, achieving adequate antibiotic drug concentrations in burn patients is challenging1. […]
ONLINE FIRST (FREE ACCESS) Understanding the Disease ~ Takeshi Yoshida et al. Understanding spontaneous vs. ventilator breaths: Impact and monitoring. From the Inside ~ Thomas Bein. Successful repair of aortic dissection, but no more playing with the grandsons. Letter ~ Maja K. von Cube et al. Relative risk and population-attributable fraction of ICU death caused by susceptible […]
What is the real impact of no sedation during mechanical ventilation? EJRC ARTICLE REVIEW For many years, standard therapy for patients undergoing mechanical ventilation included sedation. It was seen as a way to ease patients and help them to accept the procedure. In the last decade, randomised controlled trials (RCTs) have shown that utilising […]
EJRC Article Review Paediatric sepsis definitions are based upon expert consensus from the International Paediatric Sepsis Consensus Conference [1]. The adult Sepsis-3 update on definitions has changed how patients with sepsis are identified, thus impacting on the research and quality indicators associated with its management [2]. Schlapbach et al. compared the performance of SIRS, […]
Reviving glucocorticoids to treat Sepsis? EJRC Article Review Certainly, one of the greatest calamities of the modern world is Sepsis, which, despite the great advances in medicine, still doesn’t have a specific pharmacological treatment. This could be explained by the nature of Sepsis, as a very complex pathological entity, capable of affecting multiple organs, […]
