Is Trimodulin a safe and beneficial adjuvant therapy for adult patients with sCAP?

Is Trimodulin a safe and beneficial adjuvant therapy for adult patients with sCAP? EJRC Article Review Severe community-acquired pneumonia (sCAP) remains associated with high mortality despite widespread use of supportive care and targeted antibiotic therapy. Evidence suggests that IgM-enriched Immunoglobulin preparations are associated with a decrease in mortality in severe sepsis and septic shock. In […]

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ICM ~ Hot off of the Presses: ONLINE FIRST articles

ONLINE FIRST (FREE ACCESS) Original ~ Fabiana Madotto et al. Resolved versus confirmed ARDS after 24h: Insights from the LUNG SAFE study. Seven-Day Profile Publication ~ Tobias Welte et al. Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomised, placebo-controlled, double-blind, multicentre, phase II trial (CIGMA study). […]

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Improving antibiotic stewardship in pneumonia: Is aggressive viral testing the key?

Improving antibiotic stewardship in pneumonia: Is more aggressive viral testing a key to success? EJRC Article Review   Pneumonia has a substantial impact in the ICU, as a leading reason of acute respiratory failure and for mechanical ventilation. Since appropriate antibiotic use is crucial to limiting morbidity and mortality in pneumonia, intensivists normally prescribe broad-spectrum […]

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Identifying community-acquired pneumonia (CAP)

Is the clinical significance of community-acquired pneumonia (CAP) visualised on CT scans only the same as of CAP visualised on chest x-rays? EJRC Article Review   The clinical significance of radiological signs of pneumonia visualised only on CT imaging is largely unknown, which creates uncertainty about the appropriate management: Should the management approach be according […]

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