Peripheral oxygenation targets in critically ill children: Pilot Oxy-PICU definitive trial

Feasibility of a definitive trial of peripheral oxygenation targets in critically ill children: pilot Oxy-PICU trial EJRC Article Review Although peripheral oxygen saturation (SpO2) monitoring is universal, the optimum target for ventilated critically ill children is uncertain. Lower SpO2targets at 85-89% is favoured in preterm infants [1]. In adults, reported mean number needed to harm […]

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Filling the evidence gap: Decontamination of Oral/Digestive Tract for ICU Patients

CLINICAL TRIAL RESULTS icTV Interview In this icTV interview, Bastiaan H. Wittekamp (Utrecht, Netherlands) describes the results of his multinational cluster randomised clinical trial on decontamination strategies in ICUs. Results from this trial were presented during the Presidents’ Ground Breaking Research Release Session at LIVES 2018 in Paris and were published in JAMA. Watch the President’s Session at LIVES […]

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CLINICAL TRIALS RESULTS ~ The BREATHE Study (with link to paper)

Does early extubation using a protocolised noninvasive weaning regimen reduce the time to liberation from ventilation compared with protocolised invasive weaning? (icTV) Updated interview with Gavin Perkins   Gavin Perkins (Coventry, United Kingdom) rejoins us in the icTV studio at LIVES 2018 in Paris to discuss the Breathe study, the initial results of which were […]

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(icTV) CLINICAL TRIALS RESULTS ~ Plasma angiopoietin-2 & ARDS risk in sepsis

(icTV) CLINICAL TRIALS RESULTS Plasma angiopoietin-2 & ARDS risk in sepsis In this icTV interview, presenter John Reilly discusses his clinical trial “Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: Evidence from mendelian randomisation and mediation analysis”. Full results from this trial were presented at the clinical trials session at LIVES 2018 […]

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Post-EOLIA trial: What’s the role of ECMO?

CLINICAL TRIAL RESULTS ECMO Bayesian analysis Following publication of the EOLIA trial, many questions remain as to the role of early venovenous extracorporeal membrane oxygenation (ECMO) in very severe ARDS.  In this icTV interview, Ewan Goligher (Toronto, Canada) describes the results of a post hoc Bayesian analysis of the EOLIA trial conducted to determine the […]

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