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(icTV) FUTURE CLINICAL TRIALS: Start with well designed animal studies…

ICM Experimental Update In this icTV interview, Mervyn Singer, Editor-in-Chief of Intensive Care Medicine Experimental (ICMx) updates us on the journal, now in its fourth year. In light of the current trend of neutral clinical trial results, he also discusses the importance of researchers refocusing on designing foundational animal studies, which can be translated into […]

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ICM: ONLINE FIRST THIS WEEK

ONLINE FIRST THIS WEEK (FREE ACCESS)   What’s New in Intensive Care ~ Stephen M. Pastores et al. Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part II): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017. Editorial ~ Carmel Montgomery […]

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(icTV) Airways, invasive and noninvasive mechanical ventilation

What are the current advances in mechanical ventilation? Where do we go from here? Samir Jaber discusses the article focused on airways, invasive and noninvasive mechanical ventilation from the special research agenda issue of Intensive Care Medicine (ICM). Read this free access paper in ICM here. Interested in reading the other topical research agenda papers […]

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ARDS: What is the optimal PEEP?

EJRC Article Review Effect of lung recruitment and titrated positive end-expiratory pressure (PEEP) vs. low PEEP on mortality in patients with ARDS   Acute Respiratory Distress Syndrome (ARDS) is a clinical syndrome with various etiologies that usually occurs between 24 and 48 hours after local injury (pulmonary ARDS) or generalised acute illness (extrapulmonary ARDS). It […]

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Sepsis: Effect of a multifaceted educational intervention for anti-infectious measures on mortality

icTV interview with author Frank Bloos   In this icTV interview, Frank Bloos discusses the results of his prospective cluster-randomised trial MEDUSA – Medical Education for Sepsis Source Control and Antibiotics, which aimed to confirm that shortening the time to initiation of AT improves patient survival and evaluated the potential benefit of a multifaceted educational […]

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Can education improve Sepsis source control & antimicrobial therapy?

EJRC Article Review   In severe sepsis and septic shock, timing and appropriateness of antimicrobial therapy (AT) and source control have been associated with good outcome in many retrospective studies. Thus, guidelines recommend providing antibiotics in the first hour and source control in 6 to 12 hours despite the lack of randomised trials confirming this association. […]

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Early APRV: A strategy that reduces mortality and ventilator days?

EJRC Article Review Reducing the duration and harm of mechanical ventilation remains a major focus within intensive care medicine. The two predominant mechanisms of ventilator induced lung injury are volutrauma and atelectrauma [1]. Mortality from ARDS remains elevated despite significant improvements following the ARDSNet and PROSEVA studies [2,3]. Airway pressure release ventilation (APRV) has been […]

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Can KDIGO panel guidelines prevent cardiac surgery-associated AKI?

The PrevAKI RCT EJRC Article Review Patient morbidity associated with post-operative AKI following cardiac surgery is significant. Despite this we lack any specific therapy for post-cardiac surgery AKI. The management is limited to preventative and supportive measures, for which the evidence is limited. Novel biomarkers including urinary tissue inhibitor of metalloproteinase- 2 (TIMP-2) and insulin-like […]

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SPECIAL ISSUE ~ The ICM Research Agenda

ICM RESEARCH AGENDA (FREE ACCESS)   Michael A. Gillies et al. Current research priorities in perioperative intensive care medicine. Alain Combes et al. The ICM research agenda on extracorporeal life support. Hans Flaatten et al. The status of intensive care medicine research and a future agenda for very old patients in the ICU. Pratik P. […]

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(icTV) Critically ill oncology and haematology patients

SPECIAL ISSUE: The Research Agenda in Intensive Care Medicine The Editor in Chief of Intensive Care Medicine (ICM) Élie Azoulay discusses the recent issue of the journal focused on where we are with regards to research in specific disciplines within intensive care. He delves into the some important messages from the paper exploring the research […]

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