On Friday 13, two papers set for publication in the ICM Journal were presented at LIVES 40.

Ground-Breaking Release 1, 10:50 – 11:20 CEST, Exhibition TV Studio, Channel 1 

Bouglé A. et al. Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial. The iDIAPASON study.

Compared to long duration of antibiotic therapy, a short duration has a comparable clinical efficacy for ventilator-associated pneumonia (VAP), with the exception of documented VAP of non-fermenting Gram negative bacilli (NF-GNB), including Pseudomonas aeruginosa (PA). This paper aimed to assess the non-inferiority of a short duration of antibiotics (8 days) vs. prolonged antibiotic therapy (15 days) in VAP due to PA (PA-VAP).

Read the Editorial

Ground-Breaking Release 2, 16:30 – 17:00 CEST, Exhibition TV Studio, Channel 1 

Meduri G.U. et al. Low-dose Methylprednisolone Treatment in Critically Ill Patients with Severe Community-acquired Pneumonia.

Severe community-acquired pneumonia (CAP) requiring intensive care unit admission is associated with significant acute and long-term morbidity and mortality. The paper hypothesised that downregulation of systemic and pulmonary inflammation with prolonged low-dose methylprednisolone treatment would accelerate pneumonia resolution and improve clinical outcomes.