Systemic Inflammation and Sepsis

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The Systemic Inflammation and Sepsis section is led by Lene Russell.

SIS News

ICM Online First: latest results from ARDS, lung and burnout studies
ARTICLE
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Get the latest articles from our ICM Journal. Listen to ESICM podcasts for insights on…
ICMx – Article of the week
ARTICLE
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Each week, we spotlight one standout publication from Intensive Care Medicine Experimental — bringing you…
The Future Role of Professional Societies
ARTICLE
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New ESICM Talk – Professor Jan De Waele, ESICM past president, reflects on the role…

WhatsApp Community

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RESOURCES

EDUCATION

Courses

Sepsis, Severe Infections and Stewardship Pathway

Webinars and Podcasts

Webinars

– Surviving Sepsis Campaign Serie
– From ship to ICU: hantavirus preparedness in Europe
– Sepsis: back to basics
– Non-bacterial Sepsis

Podcasts

– When and how vasopressors in Sepsis?
– Multimodal approach to vascular failure in Sepsis

Free webinars and podcasts are available for members & non members on LIVES-STREAM.
Use your ESICM credentials or create an account

Inspiring Intensivist

Richard Hotchkiss

Jean-Louis Vincent

RESEARCH

Projects

SICU II
Sepsis in the ICU-II: Precision medicine models for sepsis-induced myocardial dysfunction.

Guidelines & Consensus
  • 2026
    • Prescott, H.C., Antonelli, M., Alhazzani, W. et al. Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2026. Intensive Care Med (2026). https://doi.org/10.1007/s00134-026-08361-1.
    • Weiss, S.L., Peters, M.J., Oczkowski, S.J.W. et al. Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026. Intensive Care Med (2026). https://doi.org/10.1007/s00134-026-08360-2
  • 2024
    • Bassetti, M., Giacobbe, D.R., Agvald-Ohman, C. et al. Invasive Fungal Diseases in Adult Patients in Intensive Care Unit (FUNDICU): 2024 consensus definitions from ESGCIP, EFISG, ESICM, ECMM, MSGERC, ISAC, and ISHAM. Intensive Care Med 50, 502–515 (2024). https://doi.org/10.1007/s00134-024-07341-7
Surveys

NOAF-ICU Survey
Current Practices in the Management of New-Onset Atrial Fibrillation in the ICU

MONITOR-SS LMIC Survey
Monitoring Of hemodynamic and resuscitation practices In sepsis and sepTic shOck in Resource-limited settings

Relevant Literature

– Tabah, A., De Waele, J., Ssi Yan Kai, N. et al. Source control in bloodstream infections in patients with sepsis, septic shock, or requiring ICU admission: a scoping review with recommendations for standardizing research. Intensive Care Med 51, 1462–1475 (2025).

– Halvorsen, P., Marks-Hultström, M., Wallin, E. et al. Health-related quality of life and functional recovery after intensive care for sepsis in a national cohort. Intensive Care Med 51, 1282–1291 (2025).

– Payen, D., Velho, T.R. & Moita, L.F. Beyond inflammation: the role of metabolic dysregulation in sepsis diagnosis and treatment. Intensive Care Med 51, 1359–1362 (2025).

– Kalimouttou A, Kennedy JN, Feng J, et al. Optimal Vasopressin Initiation in Septic Shock: The OVISS Reinforcement Learning Study. JAMA. 2025;333(19):1688–1698.

– The ANDROMEDA-SHOCK-2 Investigators for the ANDROMEDA Research Network, Spanish Society of Anesthesiology, Reanimation and Pain Therapy (SEDAR), and Latin American Intensive Care Network (LIVEN). Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock: The ANDROMEDA-SHOCK-2 Randomized Clinical Trial. JAMA. 2025;334(22):1988–1999. doi:10.1001/jama.2025.20402

– Giamarellos-Bourboulis EJ, Kotsaki A, Kotsamidi I, et al. Precision Immunotherapy to Improve Sepsis Outcomes: The ImmunoSep Randomized Clinical Trial. JAMA. 2026;335(9):775–786. doi:10.1001/jama.2025.24175

– Dark P, Hossain A, McAuley DF, et al. Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial. JAMA. 2025;333(8):682–693. doi:10.1001/jama.2024.26458

– Girardis, M., David, S., Ferrer, R. et al. Understanding, assessing and treating immune, endothelial and haemostasis dysfunctions in bacterial sepsis. Intensive Care Med 50, 1580–1592 (2024).

– Leone, M., Juffermans, N.P. & Nielsen, N.D. Ten tips on fever. Intensive Care Med 49, 587–590 (2023).

Point of view
2025
2024