Systemic Inflammation and Sepsis
The Systemic Inflammation and Sepsis section is led by Lene Russell.
SIS News
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RESOURCES
EDUCATION
Courses
Sepsis, Severe Infections and Stewardship Pathway
Webinars and Podcasts
Webinars
– Surviving Sepsis Campaign Serie
– Sepsis: back to basics
– Non-bacterial Sepsis
Podcasts
– When and how vasopressors in Sepsis?
– Multimodal approach to vascular failure in Sepsis
Free webinars and podcasts are available for members & non members on LIVES-STREAM.
Use your ESICM credentials or create an account
RESEARCH
Projects
SICU II
Sepsis in the ICU-II: Precision medicine models for sepsis-induced myocardial dysfunction.
Guidelines & Consensus
- 2026
- Prescott, H.C., Antonelli, M., Alhazzani, W. et al. Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2026. Intensive Care Med (2026). https://doi.org/10.1007/s00134-026-08361-1.
- Weiss, S.L., Peters, M.J., Oczkowski, S.J.W. et al. Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026. Intensive Care Med (2026). https://doi.org/10.1007/s00134-026-08360-2
- Prescott, H.C., Antonelli, M., Alhazzani, W. et al. Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2026. Intensive Care Med (2026). https://doi.org/10.1007/s00134-026-08361-1.
- 2024
- Bassetti, M., Giacobbe, D.R., Agvald-Ohman, C. et al. Invasive Fungal Diseases in Adult Patients in Intensive Care Unit (FUNDICU): 2024 consensus definitions from ESGCIP, EFISG, ESICM, ECMM, MSGERC, ISAC, and ISHAM. Intensive Care Med 50, 502–515 (2024). https://doi.org/10.1007/s00134-024-07341-7
Surveys
NOAF-ICU Survey
Current Practices in the Management of New-Onset Atrial Fibrillation in the ICU
MONITOR-SS LMIC Survey
Monitoring Of hemodynamic and resuscitation practices In sepsis and sepTic shOck in Resource-limited settings
Relevant Literature
– Tabah, A., De Waele, J., Ssi Yan Kai, N. et al. Source control in bloodstream infections in patients with sepsis, septic shock, or requiring ICU admission: a scoping review with recommendations for standardizing research. Intensive Care Med 51, 1462–1475 (2025).
– Halvorsen, P., Marks-Hultström, M., Wallin, E. et al. Health-related quality of life and functional recovery after intensive care for sepsis in a national cohort. Intensive Care Med 51, 1282–1291 (2025).
– Payen, D., Velho, T.R. & Moita, L.F. Beyond inflammation: the role of metabolic dysregulation in sepsis diagnosis and treatment. Intensive Care Med 51, 1359–1362 (2025).
– Kalimouttou A, Kennedy JN, Feng J, et al. Optimal Vasopressin Initiation in Septic Shock: The OVISS Reinforcement Learning Study. JAMA. 2025;333(19):1688–1698.
– The ANDROMEDA-SHOCK-2 Investigators for the ANDROMEDA Research Network, Spanish Society of Anesthesiology, Reanimation and Pain Therapy (SEDAR), and Latin American Intensive Care Network (LIVEN). Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock: The ANDROMEDA-SHOCK-2 Randomized Clinical Trial. JAMA. 2025;334(22):1988–1999. doi:10.1001/jama.2025.20402
– Giamarellos-Bourboulis EJ, Kotsaki A, Kotsamidi I, et al. Precision Immunotherapy to Improve Sepsis Outcomes: The ImmunoSep Randomized Clinical Trial. JAMA. 2026;335(9):775–786. doi:10.1001/jama.2025.24175
– Dark P, Hossain A, McAuley DF, et al. Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial. JAMA. 2025;333(8):682–693. doi:10.1001/jama.2024.26458
– Girardis, M., David, S., Ferrer, R. et al. Understanding, assessing and treating immune, endothelial and haemostasis dysfunctions in bacterial sepsis. Intensive Care Med 50, 1580–1592 (2024).
– Leone, M., Juffermans, N.P. & Nielsen, N.D. Ten tips on fever. Intensive Care Med 49, 587–590 (2023).
