Thrombotic thrombocytopenic purpura (TTP) is a haematological and critical care emergency, with a 90% mortality rate if left untreated. The severity of TTP varies, and no consensual definition of severe TTP exists. Many patients with TTP require ICU admission, either due to severe organ failure or because the ICU is the only place in the hospital where PEX can be performed, a central line is inserted, and close monitoring is provided around the clock. Close monitoring is crucial, as sudden death can occur at any time during the first days of treatment, chiefly from cardiac microvasculature occlusion, arrhythmia, or cardiogenic shock. In a retrospective study of thrombotic microangiopathy (TMA) comparing survivors and nonsurvivors, the main factors associated with death were the absence of PEX and cardiac involvement.
Celebrating the TTP centenary will be a unique opportunity to improve the management skills of a wide range of healthcare professionals managing TTP patients, from those facing diagnostic challenges to TTP specialists managing acute TTP disease and relapses, or longer-term outcomes.
This 6-hour multi-disciplinary and interprofessional TTP-skills training programme comprises five 1h15 webinars. This series of online live webinars offers flexibility, allowing participants from various disciplines, countries, and time zones to access the content at their own pace and convenience. Additionally, it provides a diverse range of multimedia resources, fostering a dynamic learning environment that accommodates different learning styles, making it an effective means of knowledge transfer for a multidisciplinary audience. The programme will include worldwide specialists whose scientific contribution has reshaped TTP management and outcomes.
ABOUT THE WEBINARS
LEARNING OUTCOMES
The TTP Centenary programme will encompass five key objectives:
- To explore the significant milestones in TTP research and their implications for major clinical advancements.
- To understand the pathophysiology of organ involvement in TTP and maintain diagnostic awareness across various medical specialities.
- To grasp the therapeutic targets for TTP and cTTP.
- To outline the best standards of care for adults and children with aTTP and cTTP, with a special focus on pregnancy-related considerations.
- To update delegates on current research endeavours aimed at advancing patient management.
TOPICS & DATES
Webinar 1: How Did It Happen?
2 Sept 2024
- Introduction to the TTP centenary by Elie Azoulay
- Syndromes of thrombotic microangiopathy by Fadi Fakhouri
- Revisiting the Moschcowitz syndrome: 1924-2024 by Paul Coppo
- From an incurable disease to a treatable disorder by Bernhard Lämmle
- The discovery of ADAMTS13 in acquired TTP, a turning point by Agnès Veyradier
Webinar 2: TTP Diagnosis
09 Sept 2024
- Understanding the challenge. Shruti Chaturvedi
- From thrombotic microangiopathies to TTP: The devil is in the details. Katerina Pavenski
- Clinical algorithms for TTP diagnosis. Spero Cataland
- Inherited ADAMTS13 mutations associated with Thrombotic Thrombocytopenic Purpura. Nathalie Biebuyck
Webinar 3: Specific situations
16 Sept 2024
- Introduction: TTP a group of heterogeneous disorders, Allyson Pishko
- TTP in pregnancy. Marie Scully
- Pediatric thrombotic thrombocytopenic purpura. Berangere Joly-Laffargue
- The clinical spectrum of TTP without anti-ADAMTS13 antibodies. Masanori Matsumoto
Webinar 4: The sickest TTP patients
23 Sept 2024
- Introduction by Katia Donadello
- Organ dysfunction in TTP. Elie Azoulay
- Cardiac involvement in acute and relapsing TTP. Ygal Benhamou
- Neurological complications in TTP: Eric Mariotte
- Conclusion of the Webinar by Ygal Benhamou
Webinar 5: Therapeutic Targets
30 Sept 2024
- Introduction by María Eva Mingot Castellano
- A Standard of Care for the management of acquired TTP: Paul Coppo
- A standard of care for the management of Hereditary TTP. X LONG ZHENG
- Current and upcoming development in TTP management: Paul Knoebl
- Future drugs and therapeutic strategies in patients with TTP. Flora Peyvandi
- Conclusion of the Webinar by Lara Zafrani
IMPORTANT NOTE
We are excited to announce that the TTP webinar series is available for on-demand viewing on the Academy.
Each webinar offers an opportunity to earn 2 CME credits. To successfully claim your credits, please follow these simple steps:
- Watch the recorded session on the ESICM Academy at your convenience.
- Complete a brief assessment quiz.
- Submit the post-webinar evaluation form.
Both the quiz and evaluation form are readily accessible for each webinar on the Academy, ensuring a seamless experience. Don’t miss out on this valuable opportunity to enhance your professional development!
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