An ESICM Talk powered by the ESICM Acute Kidney Injury Section
Preclinical models of acute kidney injury (AKI) consistently demonstrate that a uremic milieu enhances renal recovery and decreases kidney ﬁbrosis.
Reduced renal clearance has the surprising and counterintuitive eﬀect of being an eﬀective treatment for AKI.
In this perspective, Dr Lakhmir S. Chawla suggests a hypothesis describing why the uremic milieu is kidney protective and proposes a clinical trial of ‘permissive azotemia’ to improve renal recovery and long-term renal outcomes in critically ill patients with severe AKI.
Hear more about the explanation of this hypothesis in the following podcast, organised by the ESICM AKI Section.