May 17, 2023

Intensive Care Bites

An ESICM Talk powered by the ESICM Acute Kidney Injury Section


Preclinical models of acute kidney injury (AKI) consistently demonstrate that a uremic milieu enhances renal recovery and decreases kidney fibrosis.

Reduced renal clearance has the surprising and counterintuitive effect of being an effective treatment for AKI.

In this perspective, Dr Lakhmir S. Chawla suggests a hypothesis describing why the uremic milieu is kidney protective and proposes a clinical trial of ‘permissive azotemia’ to improve renal recovery and long-term renal outcomes in critically ill patients with severe AKI.

Hear more about the explanation of this hypothesis in the following podcast, organised by the ESICM AKI Section.

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