QUIZ #2 – INF

Biomarker-guided strategy in critically ill adults treated for suspected sepsis

Correct answer: B

Explanation: In the ADAPT-Sepsis trial, PCT-guided discontinuation of antibiotics reduced duration compared to standard care, whereas CRP-guided discontinuation did not show the same benefit. The trial evaluated both antibiotic duration and 28-day mortality as effectiveness and safety outcomes. 

Reference: Dark et al., JAMA 2025, ADAPT-Sepsis randomised clinical trial