QUIZ #2 – SIS

Potential treatment targets in sepsis

Girardis, G., David, S., Ferrer, R., et al. Understanding, assessing and treating immune, endothelial and haemostasis dysfunctions in bacterial sepsis. Intensive Care Med 2024.

Correct answers: 2 & 4

Explanation: In sepsis, steroids are used to blunt the hyperinflammatory response rather than the hypoinflammatory response. Albumin restores blood pressure and is an endothelial surface layer stabilizer. Complement inhibitors prevent the procoagulant effects of the cross-talk between complement and the haemostatic system, while checkpoint inhibitors modulate cytokine production.