QUIZ #1 – AKI

Septic shock with AKI stage 2

Correct Answer: A

Explanation:

• A is true — loading dose depends on volume of distribution, not renal clearance, so AKI does not require reduction initially.
• B is false — T>x4MIC applies to β-lactams; aminoglycosides are concentration-dependent (Cmax/MIC ≥8–10).
• C is false — nephrotoxicity still occurs despite trough monitoring.
• D is false — Cmax/MIC ≥8–10 applies to aminoglycosides, not penicillins.

References:
1. Roberts JA et al. Clin Infect Dis. 2011;52(9):1232-1239.
2. Pea F, Viale P. Clin Pharmacokinet. 2009;48(4):233-261.
3. Craig WA. Clin Infect Dis. 1998;26(1):1-12.