September 29, 2019

Monday 30 September,16.00 - 18.05, Room Berlin

Thematic Session ~ Presidents’ Ground Breaking Research Release

MONDAY 30 SEPTEMBER – PRESIDENTS’ GROUND-BREAKING RESEARCH RELEASE

moderated by J Kesecioglu (Utrecht, Netherlands) & M Cecconi (Milan, Italy)

 

Monday will be an opportunity to watch live (at work, home or at the Congress) six thematic sessions moderated by the ESICM President and President elect:

  • DIANA study – presented by L. De Bus (Gent, Belgium) – Watch the presentation on E-LIVES
  • RCT in 180 cardiac surgery patients investigating the immunomodulatory and renal protective effects of a beta-HCG derivative – presented by P. Pickkers (Nijmegen, Netherlands) – No recording available
  • Large RCT with 700 patients; NONSEDA study – presented by P. Toft (Odense, Denmark) Watch the presentation on E-LIVES
  • WEAN SAFE study – presented by J. Laffey (Galway, Ireland) & G. Bellani (Milan, Italy) & T. Pham (Toronto, Canada) – No recording available
  • The ICU Visits Randomized Clinical Trial – presented by R. Goulart Rosa (Porto Alegre, Brazil)Read the article – Watch the presentation on E-LIVES
  • French ICU diary RCT – presented by J.-F. Timsit (Paris, France) – Read the article –  Watch the presentation on E-LIVES

 

RCT in 180 cardiac surgery patients investigating the immunomodulatory and renal protective effects of a beta-HCG derivative – presented by P. Pickkers (Nijmegen, Netherlands)

Pregnancy is associated with immunotolerance and an increased glomerular filtration rate. EA-230 is a newly developed synthetic linear tetrapeptide derived from the “pregnancy hormone” human chorionic gonadotropin.

EA-230 attenuated the inflammatory response in a phase 2a study performed during human experimental endotoxemia. The safety, immunomodulatory and renoprotective properties of EA-230 in 180 patients who underwent cardiac surgery will be presented during this session.

Professor Peter Pickkers is an internist-intensivist from Radboud University Medical Centre, Nijmegen (the Netherlands). His research focuses on pharmacological modulation of the immune response and the consequences for organ function, with a focus on the kidney and brain. He has co-authored 400 publications.

 

 


 

 

 

WEAN SAFE study – presented by J. Laffey (Galway, Ireland) & G. Bellani (Milan, Italy) & T. Pham (Toronto, Canada)

Successful weaning of patients from invasive mechanical ventilation is a key step in the recovery process following severe respiratory failure, and is a key clinical challenge for ICU clinicians. Delayed or unsuccessful weaning contributes directly to poorer patient outcomes. Unfortunately, the weaning process is not well defined, with wide variations in definitions and practices.

The WEAN SAFE study is an international prospective observational cohort study, carried out in 483 ICUs across 50 countries worldwide, that screened over 10,000 patients and enrolled over 6,000 patients that received at least 2 days of invasive ventilation.

At LIVES 2019, Dr Pham and Laffey will present the initial findings from this study, and will describe the impact of delayed weaning, current approaches to weaning, and the utility of existing classification systems to ‘real world’ weaning.

John Laffey is Professor of Anaesthesia Intensive Care Medicine at the School of Medicine of the National University of Ireland Galway, Vice-Dean for Research at the College of Medicine, Nursing and Health Sciences at NUI Galway, and Professor of Anaesthesia, Critical Care Medicine and Physiology at the University of Toronto (Canada). Previously, he was founding Co-Director of the Critical Illness and Injury Research Centre at the Keenan Centre for Biomedical Research of St Michael’s Hospital, Canada.

John was Co-Principal Investigator of the LUNG SAFE global epidemiologic study. His basic and translational research is focused on acute respiratory distress syndrome and sepsis.

Dr Giacomo Bellani is Associate Professor of Anesthesia and Critical Care Medicine of the University of Milan-Bicocca, in Monza, Italy, and staff physician in the general Intensive Care Unit of San Gerardo Hospital, Monza, Italy, where he completed the postgraduate training programme in Anesthesia and Critical Care.

In 2003-2004, he was Research Fellow at Massachusetts General Hospital, Boston, MA. In 2010, he acquired a PhD in Biomedical Technology at UNIMIB (University of Milano-Bicocca), Italy

Research has always been complementary to his clinical activities. His research is largely focused on ARDS and mechanical ventilation monitoring. From October 2015 to October 2018 he was Chairman of the Acute Respiratory Failure Section of ESICM.

Giacomo is co-PI of the WEAN SAFE Study and also the LUNG SAFE study (main manuscript published in 2016 on JAMA). He is a member of the SMART meeting Organising Committee.  He has authored 120 peer-reviewed papers, 10 book chapters and delivered 150 invited talks.

Tài is an intensivist and researcher working at Kremlin-Bicêtre, France.  He completed his training in Anesthesia and Intensive Care in Paris, followed by a post-Doctoral Fellowship in Professor Laurent Brochard’s lab in Toronto, Ontario, Canada.  His qualifications include a PhD in Public Health, and several university degrees in the field of Critical Care.

His research is mainly focused on respiratory physiology, mechanical ventilation and epidemiology. He is a member of the LUNG SAFE Executive Committee and is active in the WEAN SAFE studies endorsed by the ESICM. He has also been involved in several other research networks, including the ReVA network (http://www.reseau-reva.org/) and the ECMOnet (http://www.internationalecmonetwork.org) and the center of excellence in mechanical ventilation in Toronto (https://coemv.ca/).

 

The ICU Visits Randomized Clinical Trial – presented by R. Goulart Rosa (Porto Alegre, Brazil) 

This presentation will address the results of a pragmatic cluster-randomized crossover trial comparing patient, family and staff outcomes associated with a flexible family visitation policy (12 hours per day, plus family education) or the standard restricted visitation (median 1.5 hours per day) in 36 adult ICUs with restricted visiting hours in Brazil.

Regis Goulart Rosa, MD, MSc, PhD is a Critical Care Physician and Researcher at Hospital Moinhos de Vento, Porto Alegre, Brazil.  He is also an Executive Committee member of Brazilian Research in Intensive Care Network (BRICNet).

 


 

Watch the full session on ESICM Live TV starting Monday at 16:00.

The webcasts of these research presentations will shortly be available.

 #ICU #LIVES2019

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