Organised by the ESICM Intensive Care Medicine Experimental (ICMx) Journal, this webinar will present current approaches in sepsis research, with particular emphasis on host stress responses, and discuss the importance of the concepts of phenotyping and endotyping in sepsis.
- Understand host stress responses, particularly concerning species-specific survival strategies, multiple stressors and resource availability.
- Recognise gaps in knowledge of organ- and tissue-specific host defence responses.
- Identify endotypes or phenotypes that respond to therapy in sepsis patients and for future expansion of clinical trials.
- Understand the relevance of macrophage activation syndrome (MAS) as a hyperinflammatory syndrome on outcomes in septic patients.
- Characterise the presenting signs of MAS, diagnostic challenges and potential strategies to identify it in sepsis patients and enrich clinical trials.
Topics & Experts
“Changing the sepsis paradigm – lessons from stress biology”
Prof Michael BAUER
Center for Sepsis Control Care (CSCC), University Hospital Jena (DE).
“Sepsis with liver dysfunction and coagulopathy predicts an inflammatory pattern of macrophage activation”
Prof Hernando GOMEZ
University of Pittsburgh Medical Center (USA).
Prof Nicole JUFFERMANS
OLVG Hospital, Amsterdam (NL)
ICMx Journal Editor-in-Chief
Prof Mervyn SINGER
University College London (UK)
Former ICMx Journal Editor-in-Chief