August 23, 2018

Intensive Care Medicine Experimental

ICMx NEW ARTICLE ALERT: Pre-clinical Sepsis Study Guidelines

OPEN ACCESS link + icTV video & podcast interview with the author

A number of negative or neutral sepsis clinical trials in recent years have cast a shadow of cynicism over the potential of future studies. Experts have reiterated the need to go back to the drawing board (so to speak) and re-focus on basic science with pre-clinical trials. However, one of the criticisms related to this type of sepsis research is a lack of homogeneity in animal study design.

A group of experts from the field formed a conference in Vienna in May 2017 to address this deficit, and have drafted a set of guidelines, defined as the “Minimum Quality Threshold in Pre-Clinical Sepsis Studies” (MQTiPSS). The overall aim? To enhance the translational value of these models.

A review of their resulting paper has now been published in Intensive Care Medicine Experimental (ICMx), Infection and Shock.

LISTEN TO THE icPODCAST ~ Click here to listen to an icPodcast with lead author Marcin F. Osuchowski

READ THE ARTICLE ~ Marcin F. Osuchowski et al. Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. Original publication: 14 August 2018.

WATCH THE VIDEO ~ Click below to watch a brief animated overview of the rationale and design of the consensus paper.

Do you want to access more ground-breaking experimental research? Check out more new papers in ICMx in OPEN ACCESS here.

Interested in submitting your work for publication? Learn more here.


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