October 2, 2016



Chairs Michael Bauer (Jena, Germany) and Can Ince (Amsterdam, Netherlands) lead this session focused on the basic and experimental research hosted in our online open access journal ICM Experimental (ICMx).

In his presentation, John Laffey (Toronto, Canada) describes What we can learn from… Lung Injury Models:

The relative success of Lung Injury models in contributing to our understanding of the pathogenesis of Acute Respiratory Distress Syndrome (ARDS) stands in marked contrast to their failure to discover a therapy for  ARDS. This talk will highlight the success of preclinical research and examine the reasons behind the translational failures, and the contribution of the limitations of our current translational paradigms to these failures.

In her presentation centred on brain and spinal cord injury models Elisa Zanier (Milan, Italy) notes that the well established gap between successful experimental interventions in animal models and failures in clinical applications.

The focus of Zanier's talk will be on the importance of a lively connection between the laboratory and the clinical work. Parallel exploration of mechanisms in the laboratory and in the clinical setting (through neuro-imaging etc..) are essential to refine experimental models, improve preclinical studies and develop neurorestorative treatments.

ICMx Editor-In-Chief Mervyn Singer (London, United Kingdom) covers what can be learned from sepsis models and finally Peter Pickkers (Nijmegen, Netherlands) updates us on what essential knowledge can be acquired from human models: 

Many pharmacological discoveries are made in laboratory and animal studies, but when brought to the patient, many times the clinical results are disappointing. Translational research, in human volunteers, using models that mimic the patient condition enables us to evaluate the mechanism of action and efficacy of interventions in humans. Administration of bacterial endotoxin to healthy volunteers is an example of a human translational model and similarities and differences of the systemic inflammation observed during endotoxemia and in patients with sepsis or multiple trauma will be discussed.


Don't miss this key translational session…   

From Bench to Bedside Session ~ ICM EXPERIMENTAL 1: WHAT CAN WE LEARN FROM…

03.10.2016, 11:00 – 12:00, room Vienna       



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