Prophylactic melatonin for delirium in intensive care (Pro-MEDIC)
An ESICM Talk powered by the ICM Journal & the NEXT Committee
Delirium is a condition of acute organic brain dysfunction with fluctuating disturbances of attention and cognition, and its prevalence in intensive care units (ICUs) is recorded as high as 80%.
Delirium is highly distressing for patients and families and commonly reported as the worst experience of ICU admission. Melatonin has been described as an attractive intervention for delirium prevention, and a large study hypothesised that early administration of melatonin effectively reduces delirium in critically ill patients.
In this podcast, Dr Wibrow details the results of this study with Dr Scaramuzzo.