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Metabolic resuscitation is an adjunctive therapy for sepsis and septic shock, which consists of a combination of vitamin C, glucocorticoids, and vitamin B1 or their components. Recently, there has been considerable interest in this treatment. However, due to the wide range of combinations of its components, there is no evidence for the effectiveness of this therapy.

To fill this gap, a network meta-analysis (NMA) and component NMA was conducted. This analysis summarised the available evidence concerning these therapies and determined any incremental effect of each component when added to sepsis treatment.

In the following podcast, Dr Fuji explains the methodology employed and details the study results.