CLINICAL TRIALS IN INTENSIVE CARE
Tuesday October 4th, 16:00~18:00
#LIVES2016
Learn results to be published in major journals before your colleagues! Chaired by Elie Azoulay (Paris, France) and Laurent Brochard (Toronto, Canada), this session will include results from some of the most long-awaited trials of the year. Here are some more details from presenters on what you can expect to hear:
Long-term outcomes in patients with septic shock transfused at a lower versus a higher haemoglobin threshold – the TRISS randomised, multicentre, clinical trial
A restrictive haemoglobin threshold for transfusion seems safe in critically ill patients in regards to short-term survival, and this may also be the case in patients with septic shock. But before stronger recommendations are given, we need to know the effects of transfusion strategies on long-term outcomes including survival and health-related quality of life.
~ Sofie Louise Rygård
Lateral-trendelenburg position to avoid ventilator-associated pneumonia
We will present the results of the Gravity-VAP Trial, which is a prospective randomised clinical trial to test efficacy and safety of the lateral-Trendelenburg position in comparison with the semi-recumbent position for the prevention of ventilator-associated pneumonia. The study was conducted, between December 2010 and April 2015, in 18 ICUs in Italy, Spain, Germany, Croatia and USA. This ground-breaking trial challenges the current standard of care of maintaining all intubated critically ill patients in the semi-recumbent position. In 2013, the Gravity-VAP trial was endorsed by the European Society of Intensive Care Medicine.
~ Gianluigi Li Bassi
Restricting volumes of resuscitation fluid in patients with septic shock: The CLASSIC randomised, parallel-group, multicentre feasibility trial
Fluid resuscitation is a key intervention for circulatory impairment in septic shock, but there is limited high-quality data to support recommendations.
We assessed the effects of a protocol restricting resuscitation fluid vs. a standard care protocol after the initial resuscitation in ICU patients with septic shock; primarily on fluid volumes and exploratorily on patient-centred outcomes.
~ Peter Buhl Hjortrup
Improving quality of life and psychological recovery in post intensive care patients: A pragmatic multicentre randomised controlled trial, the RAPIT study
Novel approaches are needed to help improve psychological recovery in post-ICU patients. Human interactions between health professionals and patients might contribute to create a coherent illness narratives within this ICU recovery programme.
This trial raises some questions such as:
1) The effectiveness of the intervention on health-related quality of life, and sense of coherence,
2) Did we measure what we were looking for?, and
3) What is the next step in developing and accessing the effectiveness of recovery programmes?
~ Janet Froulund Jensen
The association between tracheal intubation during paediatric in-hospital cardiac arrest and survival
Little is known about the efficacy of interventions during paediatric cardiac arrest and randomised controlled trials are rare. We aimed to assess whether intubation during in-hospital cardiac arrest was associated with survival to hospital discharge. In order to do this, we used a large US registry and time-dependent propensity score matching.
"Surprisingly, and contrary to our hypothesis, intubation during paediatric in-hospital cardiac arrest was not associated with improved outcomes".
~ Lars W. Andersen
Neurally Adjusted Ventilatory Assist as an alternative to Pressure Support Ventilation – A multicentre randomised trial 
Neurally adjusted ventilatory assist (NAVA) is a ventilatory mode that personalises mechanical ventilation by tailoring the level of assistance delivered by the ventilator to the electromyographic activity of the diaphragm. We performed the first large scale multicentre randomised controlled trial on NAVA and evaluated to what extend this mode could facilitate the weaning process.
~ Alexandre Demoule
Here is the full line-up of presenters and expert commentators from this session:
Long-term outcomes in patients with septic shock transfused at a lower versus a higher haemoglobin threshold: The TRISS randomised, multicentre, clinical trial
Speaker: Sofie Louise Rygaard, Copenhagen, Denmark
Commentator: Derek Angus, Pittsburgh, United States
Lateral-trendelenburg position to avoid ventilator-associated pneumonia
Speaker: Gianluigi Li Bassi, Barcelona, Spain
Commentator: Anders Perner, Copenhagen, Denmark
Restricting volumes of resuscitation fluid in patients with septic shock: The CLASSIC randomised, parallel-group, multicentre feasibility trial
Speaker: Peter Buhl Hjortrup, Copenhagen, Denmark
Commentator: Howard Bauchner, Boston, United States
Effect of postoperative high-flow nasal cannula vs conventional oxygen therapy on hypoxemia in patients after major abdominal surgery: A randomised clinical trial
Speaker: Samir Jaber, Montpellier, France
Commentator: John Laffey, Toronto, Canada
Improving quality of life and psychological recovery in post intensive care patients: A pragmatic multicentre randomised controlled trial, the RAPIT study
Speaker: Janet Froulund Jensen, Hillerød, Denmark
Commentator: Elie Azoulay, Paris, France
The association between tracheal intubation during paediatric in-hospital cardiac arrest and survival
Speaker: Lars W. Andersen, Aarhus, Denmark
Commentator: Warwick Butt, Melbourne, Australia
Neurally Adjusted Ventilatory Assist as an alternative to Pressure Support Ventilation – A multicentre randomised trial
Speaker: Alexandre Demoule, Paris, France
Commentator: Laurent Papazian, Marseille, France
Join this exciting clinical trials session LIVE…
Thematic Session ~ CLINICAL TRIALS IN INTENSIVE CARE
04.10.2016, 16:00 – 18:00, room Milan
