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October 5, 2016

AKI AS A SYSTEMIC DISEASE

Thematic Session

Who elso but Lui Forni (Surrey, United Kingdom) and Thomas Rimmelé (Lyon, France) would be tasked with chairing this session about Acute Kidney Injury… and so much more! This thematic session takes us into the systemic underworkings of AKI with presentations from the top experts in the kidney specialty!

Update your knowledge with these top presentations delving into the world beyond simply AKI…


AKI & the Brain  

Encephalopathy is a common complication of acute kidney injury. The concept of kidney-brain crosstalk is discussed as well as the underlying mechanisms.
  

~ Catherine Bouman (Amsterdam, Netherlands)


AKI & the Gut   

The kidneys and gastrointestinal tract are intimately related in health and during chronic and acute disease.  On the simplest level gastrointestinal sources of infection are one of the most common causes of AKI in critical illness and form the basis of caecal ligation and puncture, our most clinically relevant animal model of septic AKI. However the relationship between gut and kidney is not unidirectional,  both acute and chronic kidney disease may predispose to intestinal permeability, dysregulation of mucosal immunity and systemic inflammation contributing to primary and secondary intestinal-derived sepsis and multi-organ dysfunction. A key unifying factor in GI-Renal crosstalk is the gastrointestinal microbiome and the acquisition of microbial dysbiosis in both renal disease and critical illness – predisposing to nosocomial infections, sepsis, and distant organ failure. Conversely a healthy microbiome may have direct protective effects against kidney injury – potentially mediated by GI flora-derived short chain fatty acids. These molecules are sensed by the kidney by a variety of transmembrane-receptors, including one best known as an olfactory receptor, suggesting in a very literal sense that the kidneys may be able to "smell when something's up with the gut".

~John Prowle (London, United Kingdom)


AKI & the Liver    

This presentation will discuss how acute kidney injury is more than a kidney disease.

-Why does AKI have systemic consequences?

-How are other organ systems affected?

-Can renal replacement therapy modulate these outcomes, or is it part of the problem?

“Timing and modality of RRT: one of the few things the intensivist can choose to change, but how?”

~Max Bell (Stockholm, Sweden)


AKI & the Lung    

Acute kidney injury and acute lung injury is probably the most frequent combination of organ failures encountered in the critically ill.

 

The presentation will elucidate how the failing kidney contributes to lung damage, specifically addressing the mechanisms of fluid retention and spill over of inflammatory mediators from the kidney into the circulation.

Finally, the most promising approach to interrupt the vicious circle renal damage and impaired pulmonary function will be discussed.

~Michael Joannidis (Innsbruck, Austria)


Other presentations in this unique session:

AKI & the Heart    
Matthieu Legrand (Paris, France)
    
AKI & Systemic Inflammation    
Didier Payen (Paris, France)
 

THEMATIC SESSION ~ AKI AS A SYSTEMIC DISEASE 

05.10.2016, 12:00 – 14:00, room Barcelona     

  
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