A 65-year-old male with septic shock and AKI stage 2 from cholangitis is prescribed aminoglycoside + piperacillin-tazobactam. Which is true?Loading dose unaffected by renal dysfunctionAminoglycosides need T>x4MICTrough monitoring fully prevents aminoglycoside nephrotoxicityA target Cmax/MIC≥8–10 is recommended for penicillins
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