LUNG-SAFE: Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE

LUNG-SAFE (Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE) is a multicentre, prospective, observational, 4-week inception cohort study, which has been carried out by the Acute Respiratory Failure section through the ESICM Trials Group. The study aimed to prospectively assess the burden of, management and therapeutic approaches to, and outcomes from acute hypoxaemic respiratory failure requiring ventilatory support, with a specific focus on ARDS as defined by the Berlin Definition.


Bellani et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA. February 23, 2016, Vol 315, No. 8.



Recognition and treatment of ARDS: The LUNG-SAFE Study


John Laffey & Giacomo Bellani (23/02/16) ~ icTV interview on study findings

John Laffey & Giacomo Bellani (19/12/15) ~ icTV Update with PIs John Laffey and Giacomo Bellani  

John Laffey ~ icTV interview - LUNG-SAFEOct 2013 icTV Update

Luciano Gattinoni ~ icTV interview - Utilising the ARDS Definition



All LUNG-SAFE data was collected on a voluntary basis by the investigators, under the agreement that all LUNG-SAFE investigators would have the opportunity to propose and publish studies involving data analyses, not covered by the original manuscript.

To this end, the ESICM Trials Group endorsed the “OPEN-LUNG-SAFE” initiative, whose policies for data access, publication and authorship are described the OPEN-LUNG-SAFE Data Access, Publication and Authorship Policy

To facilitate the review process of applications and to optimise the coordination of different studies, the Steering Committee of LUNG-SAFE will appoint an executive committee (OLS-EC) that will assess OPEN-LUNG-SAFE submissions.

How to propose analyses for OPEN-LUNG-SAFE?

In order to propose additional analyses for LUNG-SAFE, please carefully review OPEN-LUNG-SAFE Data Access, Publication and Authorship Policy

Proposals should be submitted by completing this form and sending it to

When submitting a proposal, please consider the list of variables available in the paper CRF available here.

For some proposals, we may determine that we have insufficient data to answer your particular question and may ask that you refine your hypothesis accordingly. For duplicate or overlapping requests, the OLS-EC will attempt to facilitate the collaboration between the proponents; if this cannot be achieved, the first investigator who submits the request will have priority.

When to propose analyses for OPEN-LUNG-SAFE?

The call is currently closed.  Further calls may be opened depending on the processing of submitted proposals.



OPEN-LUNG-SAFE Data Access, Publication and Authorship Policy

• Proposal form 


For more information, please contact