In this network meta-analysis, as compared to normothermia (37–37.8 °C), we found that deep hypothermia (31–32 °C), moderate hypothermia (33–34 °C) and mild hypothermia (35–36 °C) may have no effect on survival and functional outcome among comatose survivors of out-of-hospital cardiac arrest. However, both deep and moderate hypothermia were associated with an increased risk of arrhythmia compared to normothermia.

Original paper: Targeted temperature management following out-of-hospital cardiac arrest: a systematic review and network meta-analysis of temperature targets


Claudio SANDRONI. Institute of Anesthesiology and Intensive Care Medicine, Università Cattolica del Sacro Cuore, Rome (IT) and Department of Intensive Care, Emergency Medicine and Anesthesiology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome (IT). Associate Editor of the ICM Journal.

Jerry P. NOLAN. Department of Anaesthesia and Intensive Care Medicine, Royal United Hospital, Bath (UK) and Warwick Clinical Trials Unit, University of Warwick, Coventry (UK).

Shannon M. FERNANDO. Division of Critical Care, Department of Medicine, and Department of Emergency Medicine, University of Ottawa, Ottawa, ON (CA).

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