Evolving changes in mortality of 13,301 critically ill adult patients with COVID-19 over 8 months.

Age, frailty and adjusted mortality of critically ill patients have progressively reduced over the course of the COVID-19 pandemic. Non-invasive respiratory support has been increasingly used and was independently associated with improved 30-day survival in our study.

Future randomised trials are needed to determine if a management strategy based on early non-invasive support for respiratory failure improves outcomes.


Dr Otavio RANZANI. ICM Associate Editor. Barcelona Institute for Global Health, ISGlobal, Barcelona (ES) Pulmonary Division, Heart Institute (InCor), Hospital Das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo (BR).

Dr Fernando BOZZA. Instituto Nacional de Infectologia Evandro Chagas (INI), FIOCRUZ, and D’Or Institute for Research and Education (IDOR), Rio de Janeiro (BR).

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