Augmented renal clearance: Impact on continuously infused TZP concentrations?

Does augmented renal clearance have a negative impact on continuously infused TZP concentrations? EJRC Article Review Inappropriate antibiotic dosing has been linked to adverse infection outcomes1,2. Augmented renal clearance (ARC, >130mL/min) has been identified as a risk factor for low beta-lactam antibiotic concentrations in ICU patients 5,6. Because beta-lactam antibiotics have time-dependent killing properties, prolonging […]

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