Can cell surface markers predict risk of secondary infection?

The INFECT Study: Cell surface signatures of immune dysfunction risk stratify critically ill patients EJRC Article Review   Background In critically ill patients, immune activation is often accompanied by a state of immune depression. The persistence of this is associated with a complicated intensive care unit (ICU) course, including the development of nosocomial infections1. Objective […]

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Impact of real-time TDM on the prescription of antibiotics in burn patients

EJRC Article Review Patients with burn injuries may experience marked pharmacokinetic (PK) changes compared to healthy volunteers and patients admitted without burn injuries. These PK changes are related to both specific pathophysiologic alterations and the frequent use of supportive therapy in burn injury patients. Therefore, achieving adequate antibiotic drug concentrations in burn patients is challenging1. […]

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What is the real impact of no sedation during mechanical ventilation?

What is the real impact of no sedation during mechanical ventilation? EJRC ARTICLE REVIEW   For many years, standard therapy for patients undergoing mechanical ventilation included sedation. It was seen as a way to ease patients and help them to accept the procedure. In the last decade, randomised controlled trials (RCTs) have shown that utilising […]

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Are SOFA, SIRS, PELOD-2, and qSOFA accurate outcome predictors in children?

EJRC Article Review   Paediatric sepsis definitions are based upon expert consensus from the International Paediatric Sepsis Consensus Conference [1]. The adult Sepsis-3 update on definitions has changed how patients with sepsis are identified, thus impacting on the research and quality indicators associated with its management [2]. Schlapbach et al. compared the performance of SIRS, […]

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