Ventilator-associated complications in patients with ESBLE infections

Ventilator-associated complications in patients with ESBLE infections EJRC Article Review   Extended-spectrum b-lactamase producing Enterobacteriaceae (ESBLE) colonise a growing proportion of critically ill patients in the intensive care unit (ICU)[1]. ESBLE colonisation is an established risk factor for subsequent infections [2]. Although guidelines suggest to consider the colonisation status of patients to adjust empirical treatment […]

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Is Trimodulin a safe and beneficial adjuvant therapy for adult patients with sCAP?

Is Trimodulin a safe and beneficial adjuvant therapy for adult patients with sCAP? EJRC Article Review Severe community-acquired pneumonia (sCAP) remains associated with high mortality despite widespread use of supportive care and targeted antibiotic therapy. Evidence suggests that IgM-enriched Immunoglobulin preparations are associated with a decrease in mortality in severe sepsis and septic shock. In […]

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PCT-guided antibiotic therapy in ICU patients

Procalcitonin-guided antibiotic therapy in intensive care unit patients: a systematic review and meta-analysis EJRC Article Review   Procalcitonin (PCT) is an acute-phase protein that has been extensively studied as a specific marker of bacterial infection. Its main proposed value is reduced use of antibiotics. PCT measurement has been recommended in the most recent edition of […]

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Reducing CRBSIs in ICUs: What’s the best strategy?

Reducing CRBSIs in ICUs: What’s the best strategy? EJRC Article Review   Background Healthcare-associated infections (HAIs) are associated with increased morbidity, mortality, and additional healthcare costs. Addressing modifiable factors including infection prevention and control (IPC) practices is a cost effective means of reducing the incidence of HAIs. The Prevention of Hospital Infections by Intervention and […]

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Improving antibiotic stewardship in pneumonia: Is aggressive viral testing the key?

Improving antibiotic stewardship in pneumonia: Is more aggressive viral testing a key to success? EJRC Article Review   Pneumonia has a substantial impact in the ICU, as a leading reason of acute respiratory failure and for mechanical ventilation. Since appropriate antibiotic use is crucial to limiting morbidity and mortality in pneumonia, intensivists normally prescribe broad-spectrum […]

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Are risk factors and impact of prevention strategies the same for early- and late-onset VAP?

Are risk factors and impact of prevention strategies the same for early- and late-onset VAP? EJRC Article Review   The risk factors and impact of prevention strategies for early-onset (EOP) versus late-onset (LOP) ventilator-associated pneumonia (VAP) are still under debate. Saied and colleagues conducted a retrospective analysis of data prospectively entered from 01/1997 to 03/2016 […]

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Identifying community-acquired pneumonia (CAP)

Is the clinical significance of community-acquired pneumonia (CAP) visualised on CT scans only the same as of CAP visualised on chest x-rays? EJRC Article Review   The clinical significance of radiological signs of pneumonia visualised only on CT imaging is largely unknown, which creates uncertainty about the appropriate management: Should the management approach be according […]

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Prevention & Control of Multidrug-Resistant Gram-Negative Bacteria in ICUs

A Systematic Review and Network Meta-analysis EJRC Article Review Both the Healthcare Infection Control Practices Advisory Committee (2,3), the Centers for Disease Control & Prevention (6) and multiple other organisations (4,5) have published guidelines for the management of the increasing public health concern that is Multi-drug resistant Organisms. This is a meta-analysis into the effectiveness […]

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