+ Direct Access

Early APRV: A strategy that reduces mortality and ventilator days?

EJRC Article Review Reducing the duration and harm of mechanical ventilation remains a major focus within intensive care medicine. The two predominant mechanisms of ventilator induced lung injury are volutrauma and atelectrauma [1]. Mortality from ARDS remains elevated despite significant improvements following the ARDSNet and PROSEVA studies [2,3]. Airway pressure release ventilation (APRV) has been […]

Read More…

Can KDIGO panel guidelines prevent cardiac surgery-associated AKI?

The PrevAKI RCT EJRC Article Review Patient morbidity associated with post-operative AKI following cardiac surgery is significant. Despite this we lack any specific therapy for post-cardiac surgery AKI. The management is limited to preventative and supportive measures, for which the evidence is limited. Novel biomarkers including urinary tissue inhibitor of metalloproteinase- 2 (TIMP-2) and insulin-like […]

Read More…

(icTV) COMMENTARY: THE WHO SEPSIS RESOLUTION

Making an impact on global sepsis awareness In this icTV interview, SCCM President Ruth Kleinpell comments on the 2017 World Health Organization (WHO) resolution to improve the prevention, diagnosis and treatment of sepsis. She delves into the continuing difficulties related to the recognition of sepsis on a global public scale and the need to support one […]

Read More…

Want to reduce reintubation rates?

Reconnect to Mechanical Ventilation for 1h after a successful spontaneous breathing trial EJRC Article Review Post-extubation respiratory failure causes between 5-30% of patients to require reintubation, which is associated with increased mortality. Spontaneous breathing trials aim to evaluate when a patient is ready for extubation and involves a trial of T-tube, low level pressure support […]

Read More…

SPECIAL ISSUE ~ The ICM Research Agenda

ICM RESEARCH AGENDA (FREE ACCESS)   Michael A. Gillies et al. Current research priorities in perioperative intensive care medicine. Alain Combes et al. The ICM research agenda on extracorporeal life support. Hans Flaatten et al. The status of intensive care medicine research and a future agenda for very old patients in the ICU. Pratik P. […]

Read More…

(icTV) Critically ill oncology and haematology patients

SPECIAL ISSUE: The Research Agenda in Intensive Care Medicine The Editor in Chief of Intensive Care Medicine (ICM) Élie Azoulay discusses the recent issue of the journal focused on where we are with regards to research in specific disciplines within intensive care. He delves into the some important messages from the paper exploring the research […]

Read More…

Prevention & Control of Multidrug-Resistant Gram-Negative Bacteria in ICUs

A Systematic Review and Network Meta-analysis EJRC Article Review Both the Healthcare Infection Control Practices Advisory Committee (2,3), the Centers for Disease Control & Prevention (6) and multiple other organisations (4,5) have published guidelines for the management of the increasing public health concern that is Multi-drug resistant Organisms. This is a meta-analysis into the effectiveness […]

Read More…

ICM: ONLINE FIRST THIS WEEK

ONLINE FIRST THIS WEEK (FREE ACCESS)   What’s New in Intensive Care ~ Pierre Singer et al. What’s new in trace elements? Editorial ~ Anders Perner et al. Focus on fluid therapy. Editorial (Debate) ~ Alain Combes et al. Do we need randomised clinical trials in extracorporeal respiratory support? Yes. Editorial (Debate) ~ Luciano Gattinoni and […]

Read More…

Diaphragm weakness in the ICU: What do we know?

ICM ARTICLE REVIEW Diaphragm weakness is common in intensive care. It is associated with increased mortality and failure to wean from ventilation. Its cause in intensive care is often multi-factorial, due to both disease processes and treatment side effects. Currently there are a number of effective preventative strategies and treatments with potential future treatments under […]

Read More…

Biomarkers: A viable tool in fighting Invasive Candida infections?

EJRC Article Review Invasive Candida infections are leading causes of mortality among critically ill patients. The diagnosis of such diseases is challenging and a delayed start of the appropriate antifungal therapy was associated with a poor prognosis. Accordingly, early empirical antifungal treatment is warranted on the basis of suspected diagnosis. Observational studies have suggested that […]

Read More…