Augmented renal clearance: Impact on continuously infused TZP concentrations?

Does augmented renal clearance have a negative impact on continuously infused TZP concentrations? EJRC Article Review Inappropriate antibiotic dosing has been linked to adverse infection outcomes1,2. Augmented renal clearance (ARC, >130mL/min) has been identified as a risk factor for low beta-lactam antibiotic concentrations in ICU patients 5,6. Because beta-lactam antibiotics have time-dependent killing properties, prolonging […]

Read More…

PCT-guided antibiotic therapy in ICU patients

Procalcitonin-guided antibiotic therapy in intensive care unit patients: a systematic review and meta-analysis EJRC Article Review   Procalcitonin (PCT) is an acute-phase protein that has been extensively studied as a specific marker of bacterial infection. Its main proposed value is reduced use of antibiotics. PCT measurement has been recommended in the most recent edition of […]

Read More…

What can you do to halt AMR in your unit?

3 top strategies to fight antimicrobial resistance in the ICU   To support the 10th European Antibiotic Awareness Day and World Antiobiotic Awareness Week, November 13-19, the ANTARCTICA (ANTimicrobiAl Resistance CriTIcal CAre) – coalition, launched a call for increased awareness and action among intensive care and infectious diseases healthcare professionals to reduce antimicrobial resistance (AMR) […]

Read More…

Antimicrobial Resistance: CALL FOR ACTION

Facing the AMR challenge & providing solutions for critically ill patients 10th European Antibiotic Awareness Day Brussels, 15 November 2017. Patients in European intensive care units (ICUs) are increasingly suffering from infections caused by multidrug-resistant bacteria, which is associated with increased costs and worse outcome. The European Society of Intensive Care Medicine (ESICM) and the […]

Read More…