Our reviews of selected articles from the May edition
SEVEN-DAY PROFILE PUBLICATION ~ Feasibility and safety of extracorporeal CO2 removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study.
The SUPERNOVA study assessed feasibility and safety of extracorporeal carbon dioxide removal to facilitate ultra-protective ventilation in 95 patients with moderate ARDS. Use of ECCO2R to facilitate ultra-protective ventilation was feasible. A randomized clinical trial is required to assess the overall benefits and harms
ORIGINAL ~ Pantoprazole prophylaxis in ICU patients with high severity of disease: a post-hoc analysis of the placebo-controlled SUP-ICU trial.
In this post-hoc analysis of patients with high disease severity included in the Stress Ulcer Prophylaxis in Intensive Care Unit (SUP-ICU) trial, the authors observed higher 90-day mortality and fewer days alive without life support in patients at risk of GI bleeding assigned to pantoprazole vs placebo.
ORIGINAL ~ Lung ultrasound allows the diagnosis of weaning-induced pulmonary oedema.
Weaning-induced pulmonary oedema is a common cause of respiratory weaning failure and it could be detected with the appearance of B-lines at lung ultrasound. Weaning-induced pulmonary oedema can be diagnosed if the total number of B-lines counted at four points of the anterior chest increases by ≥ 6. These findings should be confirmed in larger populations.
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