Blood Purification in Sepsis: Are we ready for it?
Blood purification filters as a treatment option for sepsis patients make a lot of sense, to remove endotoxin and sepsis mediators in high amounts….but should we do this?
Increased levels of both endotoxin and cytokines are associated with the development of organ dysfunction and impaired outcome in septic shock patients.
Pharmacological interventions aimed to inhibit endotoxin-mediated effects or to attenuate the inflammatory response have not shown a clinical benefit in patients, possibly because very specific pathways are targeted and efficacy might be bypassed by other pathways.
Therefore, a more unspecific approach may be more effective. Several filters are now commercially available that can capture endotoxin (e.g. the polymyxin B filter), cytokine (e.g. the Cytosorb-filter), or both (e.g. the oXiris-filter).
During this 90-minute Live Debate Webinar, our expert panel will discuss the (interpretation of) currently available data, the practical consequences at the moment, and what data is needed.
Prof Peter PICKKERS, Professor of Experimental Intensive Care Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
Prof Thomas RIMMELÉ, Dept of Critical Care and Anaesthesia, Hôpital Eduard Herriot, Lyon, France
Prof Jean-Louis VINCENT, Dept of Intensive Care Medicine, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium
Date: Wednesday 18th September 2019
Time: 2:30-4:00 pm CEST
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