Augmented renal clearance: Impact on continuously infused TZP concentrations?

Does augmented renal clearance have a negative impact on continuously infused TZP concentrations? EJRC Article Review Inappropriate antibiotic dosing has been linked to adverse infection outcomes1,2. Augmented renal clearance (ARC, >130mL/min) has been identified as a risk factor for low beta-lactam antibiotic concentrations in ICU patients 5,6. Because beta-lactam antibiotics have time-dependent killing properties, prolonging […]

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Ventilator-associated complications in patients with ESBLE infections

Ventilator-associated complications in patients with ESBLE infections EJRC Article Review   Extended-spectrum b-lactamase producing Enterobacteriaceae (ESBLE) colonise a growing proportion of critically ill patients in the intensive care unit (ICU)[1]. ESBLE colonisation is an established risk factor for subsequent infections [2]. Although guidelines suggest to consider the colonisation status of patients to adjust empirical treatment […]

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Is Trimodulin a safe and beneficial adjuvant therapy for adult patients with sCAP?

Is Trimodulin a safe and beneficial adjuvant therapy for adult patients with sCAP? EJRC Article Review Severe community-acquired pneumonia (sCAP) remains associated with high mortality despite widespread use of supportive care and targeted antibiotic therapy. Evidence suggests that IgM-enriched Immunoglobulin preparations are associated with a decrease in mortality in severe sepsis and septic shock. In […]

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(icTV) Treating Multi-Drug Resistant Infections

What do we need to fight MDR infections in our patients? In this icTV video, Matteo Bassetti discusses his thoughts on where we are in regards to treatment of multi-drug resistant infections in critically ill patients. Find out more about MDR in the paper from Intensive Care Medicine (ICM): The intensive care medicine research agenda on multi-drug […]

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WEAN SAFE Study: Join by May 1st

Participate in this large-scale international study on weaning practice Co-PI John Laffey updates us on the WEAN SAFE Study – WorldwidE AssessmeNt of Separation of pAtients From ventilatory assistancE. The study is currently in the patient recruitment phase and has already registered more than 7000 patients from 250 ICUs, but there is still time for other […]

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ESICM LAUNCHES DIVERSITY TASK FORCE

The European Society of Intensive Care Medicine to promote equality with Diversity Task Force Press Release/Statement BRUSSELS ~ (29 March 2018) Globally, intensive care medicine is a multidisciplinary specialty led by women and men of various races, and ethnicities, with differing cultural backgrounds and beliefs, and practised in a wide spectrum of healthcare settings – from […]

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SAVE LIVES: Clean Your Hands

WHO’s global annual call to action for healthcare workers 5 May 2018: It’s in your hands – prevent sepsis in healthcare   Sepsis is estimated to affect more than 30 million patients every year worldwide. While it often occurs prior to a patient’s access to the health facility, sepsis can also result from care provided […]

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