Impact of real-time TDM on the prescription of antibiotics in burn patients

EJRC Article Review Patients with burn injuries may experience marked pharmacokinetic (PK) changes compared to healthy volunteers and patients admitted without burn injuries. These PK changes are related to both specific pathophysiologic alterations and the frequent use of supportive therapy in burn injury patients. Therefore, achieving adequate antibiotic drug concentrations in burn patients is challenging1. […]

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SAVE LIVES: Clean Your Hands

WHO’s global annual call to action for healthcare workers 5 May 2018: It’s in your hands – prevent sepsis in healthcare   Sepsis is estimated to affect more than 30 million patients every year worldwide. While it often occurs prior to a patient’s access to the health facility, sepsis can also result from care provided […]

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PCT-guided antibiotic therapy in ICU patients

Procalcitonin-guided antibiotic therapy in intensive care unit patients: a systematic review and meta-analysis EJRC Article Review   Procalcitonin (PCT) is an acute-phase protein that has been extensively studied as a specific marker of bacterial infection. Its main proposed value is reduced use of antibiotics. PCT measurement has been recommended in the most recent edition of […]

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Reducing CRBSIs in ICUs: What’s the best strategy?

Reducing CRBSIs in ICUs: What’s the best strategy? EJRC Article Review   Background Healthcare-associated infections (HAIs) are associated with increased morbidity, mortality, and additional healthcare costs. Addressing modifiable factors including infection prevention and control (IPC) practices is a cost effective means of reducing the incidence of HAIs. The Prevention of Hospital Infections by Intervention and […]

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ICM ~ Your weekly ONLINE FIRST articles

ONLINE FIRST (FREE ACCESS)   Letter ~ François Stéphan et al. Outcome of unexplained acute respiratory distress syndrome with diffuse alveolar damage after lung transplantation. What’s New in Intensive Care ~ Irene Telias et al. The airway occlusion pressure (P0.1) to monitor respiratory drive during mechanical ventilation: increasing awareness of a not-so-new problem. Letter ~ Gérald Chanques et […]

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(icTV) The next decade: Candida and Aspergillus infections in the ICU

Where are we with regards to fighting fungal infections in our patients? Matteo Bassetti shares his thoughts on this important topic in this new icTV interview linked to the recently published paper in Intensive Care Medicine (ICM): Intensive care medicine research agenda on invasive fungal infection in critically ill patients. Want to access other expert papers focused on future […]

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Are risk factors and impact of prevention strategies the same for early- and late-onset VAP?

Are risk factors and impact of prevention strategies the same for early- and late-onset VAP? EJRC Article Review   The risk factors and impact of prevention strategies for early-onset (EOP) versus late-onset (LOP) ventilator-associated pneumonia (VAP) are still under debate. Saied and colleagues conducted a retrospective analysis of data prospectively entered from 01/1997 to 03/2016 […]

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ICM ~ New ONLINE FIRST articles

ONLINE FIRST THIS WEEK (FREE ACCESS) ONLINE FIRST THIS WEEK   Conference Reports and Expert Panel ~ Jan J. De Waele et al. Antimicrobial resistance and antibiotic stewardship programmes in the ICU: insistence and persistence in the fight against resistance. A position statement from ESICM/ESCMID/WAAAR round table on multi-drug resistance. Letter ~ James Downar et al. […]

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