Clinical Trial Session 2

CAESAR Study (Azoulay)

Post-ICU syndrome and the burden of care on relatives. Hence the need to develop a tool to assess this.

A high CAESAR score represents higher family satisfaction with care

Conclusion – CAESAR instrument

  • new instrument based on family experience that will help develop family centred care
  • lower scores associated with higher burden
  • clinically, may be useful to identify vulnerable families

 

FLUID-TRIPS (Hammond)

Albumin studies – SAFE, VISEP, CRYSTMAS, CHEST, 6S, ALBIOS

Inter-country variation in types of fluid prescribed

Conclusion

  • signification variation in fluid use remains
  • significant secular changes in patterns of fluid resuscitation between 2007-2014
  • crytalloids still predominate
  • increased use of balanced salt solutions
  • pattern of colloid use consistent with recent RCT

SAFE TRIP study

Fluid-TRIPS protocol

 

CHECKLIST-ICU (Cavalanti)

Checklist and daily goals read out during round

No difference in mortality!

CHECKLIST ICU Trial protocol

Trial statistical analysis plan

Protocols and Hospital Mortality in Critically Ill Patients: The United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study

 

Very high volume hemofiltration with the Cascade system in septic shock patients

Cascade trial