(Prof Jeffery Lipman)
Interesting and thought provoking talk about how we might be inappropriately dosing antibiotics in our critically ill patients.
pK changes in ICU patients (also changes during the course of their ICU admission). Hence dosing is complex and studies confirm that it is very variable across ICUs.
pD properties of antibacterials and hence kill characteristics different across the various classes of antibiotics.
The problem is that trials which had looked at continuous vs intermittent dosing of antibiotics e.g. BLINGs and BLISS, have focussed on clinical cure rather than mortality. Watch out for BLING3