Category Archives: Clinical Trials

Vitamin C – a summary from @dogICUma #LIVES2020

Clinical Trials, LIVES 2020, sepsis

Vitamin C is a .. #LIVES2020

  • An ANTIOXIDANT
  • A COFACTOR in the synthesis of catecholamines
  • Aids WOUND HEALING
  • Is ANTI-INFLAMMATORY
  • Enhances IMMUNE CELL FUNCTION

The 1 which started it… Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study #LIVES2020

https://pubmed.ncbi.nlm.nih.gov/27940189/

 

Combination therapy of vitamin C and thiamine for septic shock in a multicentre, double-blind, randomized, controlled study (ATESS): study protocol for a randomized controlled trial #LIVES2020

https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-019-3542-x

The VITAMINS Randomized Clinical Trial #LIVES2020 @JAMAnetwork

https://jamanetwork.com/journals/jama/fullarticle/2759414

In conclusion on Vitamin C #LIVES2020

Can we predict defibrillation success during cardiac arrest?

Circulation, Clinical Trials, LIVES 2020

Ristagno Giuseppe, Milan

  • Coarse VF responds well to defibrillation; intermediate and fine VF – not as well
  • Defibrillation failure approaches ~75% during CPR
  • Current shockable algorithm considers all shockable situations the same and uses the time approach (Shock –> 2 min CPR –> Shock)
  • Recurrent VF /Resistant VF–> multiple defib attempts –> worse myocardial dysfunction post ROSC. Improving defib success will reduce the number of attempts and the post ROSC myocardial dysfunction
  • ECG waveform analysis during CPR can be used to individualize defibrillation attempts to improve success
  • AMplitude Spectrum Area (AMSA), one such technique, gives the area under the amplitude and frequency curve obtained from rhythm analysis during CPR
  • Higher the AMSA –> higher are the chances of successful defibrillation
  • With good chest compressions AMSA improves over time –> improved defibrillation success
  • AMSA >15.5 predicts defibrillation success and <6.5 predicts failure

  • Immediate vs delayed Defib in shockable rhythm – no superiority of one approach over the other (Cochrane meta-analysis – 2014)
  • AMSA trial ongoing. Analysis of data from the first 30 patients – quite promising (see screen shot below)
  • This might change the way we defibrillate in future!

LIVES 2020 Opening – Braille on the RECOVERY trial; Beigel on Remdesevir

Clinical Trials, COVID-19, COVID19, Infection, LIVES 2020

Some thoughts from Twitter….. #LIVES2020

RECOVERY

REMDESIVIR