THE ESICM COLLABORATIVE NETWORK: GENOSEPT

GENOSEPT: GENETICS OF SEPSIS IN EUROPE

PATIENT ENROLMENT IS ONGOING

The GenOSept project started in January 2005 when funding from the European Commission was secured, and will last a total of four years. 

This Project is funded by the 6th Framework programme of Research and Development-European Union.

We hypothesize that the fatal outcome following treatment for severe sepsis is, in part, genetically determined. This hypothesis is based on preliminary data developed by several groups from studies of small, relatively homogeneous populations. GenOSept will test this hypothesis through three phases:

• A genetic epidemiologic study of genetic predisposition to sepsis related mortality and morbidity in European intensive care units;

• This unique European dataset on the effect of genetic variation on sepsis outcomes will help to explain variation in response to new treatments for sepsis, will deliver data on gender related mortality and morbidity;

• Harmonization of standards for European high throughput genotyping and quality control by co-ordinating three major European genotyping centres (Wellcome Trust Centre for Human Genetics - Oxford, Cochin Institute - Paris, Helmholtz Zentrum Munchen - Munich).

    

GenOSept Consortium

The Consortium is co-ordinated by the ESICM. The GenOSept Steering Committee consists of a representative of each organisation partnering in GenOSept and senior physicians bringing their specific expertise in the project.

Co-Chairmen: Frank Stueber (assisted by Makbule Kobilay) & Julian Bion
Members:

M Ranieri assisted by Paolo Cotogni
J-D Chiche
K Reinhart assisted by F Bloos
C Garrard
J Rello

I Bobek
S Russwurm
A Hill
S Sarapuu
C Hinds
M Schneider
P Holloway
V Sramek

T Meitinger

Y Weiss
T Wienker

National Coordinators

They are in charge of the study implementation in their country. The following clinicians have already joined the partnership:
                    

National Coordinator for Austria: H Novak
National Coordinator for Belgium: P Damas
National Coordinator for Croatia: V Gasparovic
National Coordinator for Czech Republic: V Sramek
National Coordinator for Denmark: A Perner
National Coordinator for Estonia:  S Sarapuu
National Coordinator for Finland: J Tenhunen
National Coordinator for France: J-D Chiche
National Coordinator for Germany: F. Bloos
National Coordinator for Greece: A Armaganidis
National Coordinator for Hungary: I Bobek
National Coordinator for Iceland: S Karason
National Coordinator for Ireland: T Ryan assisted by M White
National Coordinator for Israel: Y Weiss
National Coordinator for Italy: C Bonetto
National Coordinator for Netherlands: J Hazelzet
National Coordinator for Poland: A Mickstaki
National Coordinator for Portugal: A Carneiro
National Coordinator for Serbia: M Surbatovic
National Coordinator for Spain: T Lisboa
National Coordinator for Sweden: A Aneman
National Coordinator for United Kingdom: C Hinds assisted by P Hutton



Find more information about GenOSept stakeholders in the GenOSept Who is Who. Download the document as PDF-file here or contact the GenOSept project Manager Nathalie Mathy.

Who is who March 2008

Work Packages and deliverables

The project is divided into several work packages. These include developing consensus definition, examining ethical issues in genetic testing, developing laboratory technologies and harmonising gene testing between countries, and evaluation of epidemiological and statistical techniques in the complex field of genomics. Central to the entire project is the clinical study during which we wish to obtain clinical data and a blood sample from patients with pneumonia, peritonitis, pancreatitits or bacterial meningitis.
In 2008 we will continue with patient recruitment and perform the genotyping.

WILLING TO JOIN IN?

We have about 260 ICUs from Europe and Israel on board. Please consider registering your ICU. Please fill in this form which will help us to have a better understanding of your ICU profile.

You can also take part in this challenging project as National Coordinator for European Countries which are not covered by the GenOSept collaboration or as ICU lead clinician. For more information see the GenOSept promotion material hereafter.

GenOSept slides set December05 - 224 KB

GenOSept Flyer - 399 KB

NEWS

1. Next GenOSept meeting

The GenOSept collaboration meet each month by teleconference. The next face to face meeting for the consortium is planned during the ESICM annual congress in Lisbon, Portugal in September 2008

1. We have just submitted our Third annual report to the European Commission

You will find the details of our activities outlined in the Publishable Executive Summary

MORE INFORMATION

For more information please contact the GenOSept project Manager Nathalie Mathy.

This project is supported by the ECCRN of the ESICM.

GenOSept also benefits from a grant of the European Union 6^th Framework-programme of RTD.